The Rees Hotel Queenstown announces bold expansion planThe Rees Hotel Queenstown announces bold expansion planThe Rees Hotel Queenstown is to be the centrepiece of a strategy to develop a chain of boutique hotels showcasing an authentic New Zealand experience. From the 12th of October 2018 The Rees Management Ltd (TRML), the manager of The Rees Hotel Queenstown, New Zealand, will be sold to interests associated with Pioneer Capital and current TRML board members Mark Rose and Bruce Davidson. Pioneer was attracted to the successful leadership, established culture and management of The Rees Hotel Queenstown and will leverage these assets as the key ingredients in their development strategy.Pioneer Capital is a New Zealand investment firm focused on investing in high value export-led businesses. The management sale and development plan will enable growth and future security of supply of guest numbers for The Rees Hotel, carefully targeted at the high-end international tourism market. TRML will continue to be the manager of The Rees Hotel and the entire management team and all staff will be retained. Mark Rose will continue as the CEO and the Board of Directors will comprise Bruce Davidson (Chairman), Mike Pohio (Independent Director), Randal Barrett and Shayne Shepherd (Pioneer) and Mark Rose.Mr Rose says, “We are excited to implement this strategic move which has been in the planning for some time. We aim to become a boutique New Zealand hotel company with around five hotels on the tourist route each reflecting their unique ‘place’, with the same culture and high touch service that we are proud to offer at The Rees Hotel Queenstown.”Mr Barrett commented, “Mark and his team have built an exceptional tourism offering in The Rees, and we are delighted to be partnering with them as they expand the product to address increasing inbound demand.”The Rees Hotel Queenstown opened in 2009, comprises 60 hotel rooms, 90 apartments and five Lakeside Residences and is located on the shores of Lake Wakatipu with spectacular views over the lake to the Remarkables mountains. The independent, stylish, luxury property has consistently been internationally recognized and awarded for excellence including receiving New Zealand Tourism’s top Qualmark 5 Star Hotel & Gold Business Tourism Sustainability Award in 2018 and ‘Best NZ Hotel’ two year’s running (2017 /18), in the Australasian Hotel Management Awards of Excellence. Along with awards for service, for its fine dining restaurant True South, executive chef Ben Batterbury and for its wine list, the hotel is also a leader in community service and sustainability initiatives, constantly striving to maintain and further develop the high standards it has set in the New Zealand hospitality industry.The management share sale and resulting development plan will be a very exciting opportunity for all parties and will provide benefits for apartment owners, management and staff and provide certainty of ownership and supply of capital. Source = The Rees Hotel Queenstown
June 15, 2016The Prescott Jazz Society presents JAZZ SPLASH – JUNETEETNTH FESTIVAL ”The American Jazz Timeline II” this coming Saturday & Sunday, June 18 & 19, 2016A two-day festival celebrating the Emancipation Proclamation through all-American jazz, blues and Dance with Funk from world-class musicians. This year’s 2016 Juneteenth Festival will honor the memory of the late Muhammad Ali.Sat. 11 am–11 pmBoogie Woogie/Stride Piano Blues Jazz Dance with Funk FrequencySun. 11 am–7 pmBe-Bop/Hard Bop Beyond Bop [Cabaret] * Finale Performers: Jonathan BestEric Williams MUDDBONE Trio R.D. Olson Band Funk Frequency’s Michael Weight and Trial by Fire’s Carlton Godwin Festival will conclude with Sunday’s annual Larry Wilson Cabaret Show featuring Phoenix Diva, vocalist SHERRY ROBERSON w/ Pianist Harold Land, Bassist Ray Carter, Drummer Leslie Daniels and Festival Director Milt Cannon saxophonist.Admission: $5/day Free for Teens and Jazz Society Members [Cabaret: $25 separate admission]* For tickets and more information, 928.237.7908 • www.pjazz.org
Senate to probe Tolentino’s ‘novel legal theories’ on oral agreements Garin hits back at ex-DOH consultant saying allegations are questionable, baseless Palace open to make Dengvaxia usable again as dengue cases spike “Yes, there were quite a number of individuals invited,” he added. “Given his stature, he had to invite his colleagues, people in government, and more importantly, his constituents. But it was very simple in terms of program and menu. It was a very simple meal.”Alvarez, who prodded President Rodrigo Duterte to run for President in 2016, turned 60 last Jan. 10.FEATURED STORIESNEWSINFOBREAK: Suspension of Lotto operations lifted – PaneloNEWSINFODuterte to Cayetanos: ‘Kailan kaya matapos ang dynasty niyo?’NEWSINFOIndian family caught taking items from Bali hotel, sparking criticism onlineHe was criticized for reportedly holding a weeklong birthday celebration that was highlighted by Friday’s birthday party which some people considered extravagant amid calls from Duterte for government officials to live modest lives.Among those who graced the event were Duterte, who rendered a song, as well as several lawmakers and Cabinet members. Duterte raises to P5M bounty for killers of Negros cops Don’t miss out on the latest news and information. ONE: Demetrious Johnson looks forward to putting on a show in Manila debut PBA: Rain or Shine overcomes San Miguel, McCullough’s 51 to avert sweep PCSO to focus on improving transparency of gaming activities PLAY LIST 03:26PCSO to focus on improving transparency of gaming activities01:39Sotto open to discuss, listen to pros and cons of divorce bill06:02Senate to probe Tolentino’s ‘novel legal theories’ on oral agreements01:50Palace open to make Dengvaxia usable again as dengue cases spike01:49House seeks probe on ‘massive corruption’ in PCSO01:37PCSO estimates P250M in Lotto revenue loss due to suspension PCSO chief focuses on keeping corruption out of games Philippines ‘fires off’ diplomatic protest over Chinese vessels circling Pag-asa Island Also present were Chinese Ambassador to the Philippines Zhao Jianhua and Russian Ambassador Igor Khovaev. /atmMORE STORIESnewsinfoDuterte raises to P5M bounty for killers of Negros copsnewsinfoPACC sets lifestyle check on PCSO board members, ex-GM BalutannewsinfoPalace open to make Dengvaxia usable again as dengue cases spikeMORE STORIESnewsinfoDuterte raises to P5M bounty for killers of Negros copsnewsinfoPACC sets lifestyle check on PCSO board members, ex-GM BalutannewsinfoPalace open to make Dengvaxia usable again as dengue cases spike WATCH: The Dowager Countess supercut MOST READ LATEST STORIES Presidential spokesperson Harry Roque holds a press briefing at the PIA office in Cebu City on Saturday, Jan. 13, 2018. (Photo from an RTVM video)CEBU CITY — Presidential spokesperson Harry Roque on Saturday downplayed claims that Speaker Pantaleon “Bebot” Alvarez had an “extravagant” weeklong birthday celebration.Skip“I was in the birthday party of the Speaker,” Roque told reporters in an interview at the Philippine Information Agency in Cebu City on Satutday. “It was in the City Hall of Tagum. I don’t think it can be described as ma-garbo because he only availed of the physical facilities of the City Hall of Tagum.”ADVERTISEMENT Read Next View comments
Legal Marijuana Illinois Is Now the 11th State to Legalize Adult-Use Marijuana — $2B Market Projected –shares Green Entrepreneur Podcast Listen Now Image credit: Aurimas Adomavicius | Getty Images June 26, 2019 Jeffrey L. Smith Illinois Gov. J.B. Pritzker on Tuesday signed a recreational marijuana legalization bill into law, paving the way for the creation of a potential $2 billion market with strong business opportunities.With the signature, Illinois becomes the first state in the country to legalize retail sales through its Legislature and the 11th overall to approve adult use. Pritzker’s signature was considered a fait accompli, since he had pushed legalization and announced his intention to sign the bill as soon as the legislature approved it in late May.“We’re also creating a $30 million low-interest loan program to create opportunity for entrepreneurs in the communities that deserve it the most (from the war on drugs),” Pritzker tweeted Tuesday. Experts believe Illinois’ social equity program, if successful, could become a blueprint for other MJ programs across the country.Marijuana Business Daily projects that the Illinois recreational program, which will launch Jan. 1, 2020, could generate up to $2.5 billion a year depending in part on how many tourists buy MJ products. Illinois is the second state in the Midwest to legalize recreational marijuana. Michigan voters passed a referendum last November that legalized recreational marijuana.The following are key business aspects to the Illinois measure:Existing medical marijuana license holders can begin adult-use sales on Jan. 1, 2020. There currently are 55 licensed dispensaries in the state.Illinois will award permits for up to 75 stores by May 1, 2020 as well as 40 processors and 40 craft growers by July 1, 2020.The measure calls for the state to issue licenses for an additional 110 stores, 60 craft growers and 60 processors in December 2021.Municipalities can prohibit recreational cannabis, although Chicago is expected to be open.Applicants that fall under social equity provisions receive additional points and potential financial resources and support such as low-interest loans, grants, training assistance and mentoring. Next Article This story originally appeared on Marijuana Business Daily Add to Queue Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. 2 min read The legalization measure contains social equity provisions activists believe could be a national model.
2019 Entrepreneur 360 List Contributor Thomas Smale Conferences Add to Queue Next Article Opinions expressed by Entrepreneur contributors are their own. Founder of FE International January 27, 2016 11 Ecommerce Conferences You Should Consider for 2016 Your business can demand major time — especially when you’re first getting set up or you’re in the midst of growing and scaling. But if you burn the candle on both ends, or sacrifice your health and relationships, your efforts are all for naught. Sometimes, it’s necessary to step away from your business to gain perspective.Related: 7 Conferences for Entrepreneurs Under 30Conferences can be a great way to take a break. Traveling to them, participating in their sessions and workshops and networking with other business owners can help you get out of a rut if you’re in one, think more strategically about your business and be in touch with people who can help you.Not that you need to go to every conference that’s out there. What’s important is to take time to recharge, and return to your business ready to tackle new challenges. As a business owner, I’ve also found speaking to be an effective way to grow my business. So, with those things in mind, here is a list, compiled by my team, of 11 of our favorite ecommerce conferences.1. The 10x E-Commerce EventWith over 25 speakers and 18 sessions, the 2016 10x E-Commerce Event this February will focus entirely on tactics you can use to drive more qualified traffic to your site, then convert these people into buying customers. You will learn about the ins and outs of conversion optimization, customer retention, A/B testing, marketing automation and much more.This year’s keynote speakers are Ashlee Vance, Paco Underhill and Timothy Seward. The summit will be held at the Renaissance Orlando at SeaWorld, February 10-12.2. eTail WesteTail West will be held in Palm Springs, California, February 22-25. You’ll have the opportunity to learn about a variety of topics like content marketing, mobile engagement, data and various pain points and areas that affect your business. This year’s keynote speakers include Ron Boire, Kelly McGann, Eric Anderson, Eoin Comerford, Jen Cotter and David Katz.Other eTail events will be held throughout the year at various locations:eTail Germany will be held in Berlin March 8-10.eTail Canada will be in Toronto, Ontario, May 16-19.eTail Europe happens in London, England, June 21-23.eTail East will be in Boston, August 15-18.3. eCommerceFuel LiveeCommerceFuel Live is made up of an exclusive group of six-and-seven-figure independent store owners. This year’s keynote speakers include Miracle Wanzo, Paul Lepa and David Heacock. The event will be held at The Gaylord Opryland in Nashville, Tenn., and will feature world-class musical entertainment. This three-day conference will happen October 7-10.4. MivaconAre you looking to learn about industry best practices, SEO, conversion optimization, content marketing, international ecommerce, trends in ecommerce and other related topics? The beginner-friendly Mivacon will be held in San Diego, March 9-11. The conference schedule has yet to be announced in full, but Rick Wilson will be one of the keynote speakers. 5. Sellers’ Conference For Online EntrepreneursThe Sellers’ Conference for Online Entrepreneurs — or SCOE — will be held in Philadelphia, March 23-25. The speaker roster includes Emily Murray, Rob Wray, Ashvin Kumar, Chris McCabe and others. At SCOE, you will learn about tools and trends in improving your online selling, driving more sales, optimizing your product and service offerings, expanding globally and more. The main focus is on sellers who use Amazon, eBay, Sears, Etsy and the like.Related: Conferences Are Good for Networking but Great for Marketing6. Imagine CommerceImagine Commerce is being held in Las Vegas, April 11-13. A premier Magento commerce conference, Imagine brings together more than 2,500 merchants, developers, partners and experts from more than 45 countries worldwide. Past years’ speakers have included keynotes from Malcolm Gladwell and Steve Wynn and sessions featuring brands and retailers like Toys R Us, Rebecca Minkoff, 3M, Kendra Scott, Zoetis and others.7. Internet Retailer Conference + ExhibitionThe Internet Retailer Conference + Exhibition — or IRCE — offers access to some of the leading industry experts and a one-of-a-kind exhibit hall displaying 600 of the latest solution providers. The 2016 speaker roster is comprised of Raj Aggarwal, Kelli Agnich, Gene Alvarez, Adam Audette, Rick Backus, Amy Ballantyne Rapawy and others.8. Sellers SummitSellers Summit offers an intense “workshop” experience focusing on up-to-date actionable insights — instead of feel-good stories — that entrepreneurs can use to grow their revenues. Speakers include event host Steve Chou, Scott Voelker, Greg Mercer, Toni Anderson, Andrew Youderian, Eric Siu, Spencer Haws, Andreea Ayers, Autumn Wyda, and others. The Sellers Summit takes place in Miami, May 19-21.9. Freedom Fast Lane LiveDetails are as of yet forthcoming for the 2016 Freedom Fast Lane Live conference, but it’s sure to be an incredible experience. Speaker Ryan Moran, for instance, is a true ecommerce expert. At F2L2, you will have the opportunity to meet, connect with and learn from industry leaders to stretch your mindset and be challenged to think beyond what you believe is possible in your business. My team at FE International loved the 2015 event. 10. Retail GlobalRetail Global occurs September 20-22 in Las Vegas. Its primary area of focus will be international commerce. Attendees will have the opportunity to learn from speakers from across the world and build a network of trusted contacts. This year’s speakers have yet to be announced.11. SHOPTALKFocusing on tech-based disruption in ecommerce, SHOPTALK will be held in Las Vegas May 15-18. Its wide range of speakers will include Casey Carl, Daphne Carmeli, Tracy Dinunzio, Ron Johnson, Tim Kendall, Katrina Lake, Raghav Lal, Brian Lee, Marc Lore, Julie Wainright, Janie Yu and others. At SHOPTALK, you can expect to learn the latest trends in engaging consumers.Final thoughtsAs a business owner, you’ll find that the most important investment you can make is in yourself and the future of your business. Conferences give you the chance to learn, grow and connect with others who are successful in their respective fields.Certainly, there are lots of great events out there; and it can be hard to know which to choose. But, ultimately, you will benefit from the experience, no matter what. It isn’t all about what you learn, but rather the decisions you make coming out of a conference, and the new connections you make.Related: 8 Tips to Be an Awesome Networker at Conferences 6 min read –shares The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »
Reuters Image credit: Brian Solis | Wikimedia Commons Enroll Now for $5 March 10, 2016 Twitter to Employees: We’ll Pay You to Stick Around –shares Jack Dorsey, Twitter. Twitter Next Article Add to Queue This story originally appeared on Reuters Twitter Inc. has been sweetening employee compensation packages to retain talent as the company’s user growth stalls and it stock price slides, the Wall Street Journal reported.Four top executives left the company in January, the biggest leadership exodus since co-founder Jack Dorsey returned as chief executive last year.The departures added to concerns about the company’s ability to make its product more engaging and generate more money from advertising.Twitter has been offering cash bonuses to some employees, ranging from $50,000 to $200,000 as an incentive to keep them around for another six months to a year, the Journal reported on Wednesday.The company has also granted varying amounts of restricted stock depending on when the employees started working, intending to make up for the value lost since they joined the company, the newspaper reported, citing people familiar with the matter.Twitter’s shares have lost more than 60 percent of their value over the past 12 months.”Competitive compensation, strong leadership and a confidence in the direction of the company are all key elements to having top talent,” a Twitter spokeswoman said in an email.”We are investing in all three areas to ensure we maintain these employees,” she said, without providing further details.Dorsey said in October he would give a third of his stock in the company, a stake of about 1 percent, to the employee equity pool.Later that month, he spoke about “hiring and investing in talent” and the need for “bold rethinking.”Twitter showed no growth in users in the fourth quarter. That was the first time that had happened since the company went public in 2013.Twitter’s shares were unchanged at $17.66 in light premarket trading.(Reporting by Ismail Shakil in Bengaluru; Editing by Gopakumar Warrier and Anil D’Silva) Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. 2 min read Fireside Chat | July 25: Three Surprising Ways to Build Your Brand
Zilliant’s Annual MindShare 2019 Showcases End-to-End Pricing and Sales Growth Capabilities “It’s an honor to host such a wide array of innovators – longtime customers, companies evaluating Zilliant technology, strategic partners, industry experts – in our hometown,” said Zilliant CEO Greg Peters. “The steep challenges faced by B2B organizations every day are being met head on by our customers, who have harnessed the power of their data and are using Zilliant’s intelligent technology to their advantage.”MindShare focused on distributors, manufacturers and service providers dealing with a rapidly changing business landscape across various industries, with topics such as:B2B eCommerce disruptionAdopting a Pricing Center of ExcellenceDigitization and optimizationPricing modes and methodsDistributor / manufacturer partnershipsOmnichannel pricingMarketing Technology News: Information Builders’ WebFOCUS Named a FrontRunner in Business Intelligence in Fourth Consecutive Report“When disruptors, like Amazon, are duplicating parts of your value proposition, you need to duplicate parts of theirs,” said Ian Heller, President & COO of Modern Distribution Management in his message to attendees. “Traditional B2B companies must scale with technology and become more comfortable doing business online, while offering services that are hard for disruptors to digitize.”A common theme was Zilliant’s comprehensive ability to solve pricing and sales problems big and small, from price list management to advanced, actionable AI-driven pricing and sales guidance.“We wanted to create a data-driven culture as part of our digital transformation journey,” said Mike Eppes, Managing VP of Parts at Rush Enterprises. “Zilliant has become our data science backbone for our parts operations, serving as the nexus for many of our IT systems, from CRM to eCommerce. As a result of using Zilliant’s solutions, we are achieving higher revenue and profits and are better able to anticipate our customers’ needs.”Marketing Technology News: AI-Driven Weather Data: New to Some, But It Has Been Driving CustomWeather’s Success for YearsMindShare featured interactive deep dive sessions led by veteran Zilliant customers. A&O Johansen, a major distributor of technical installation materials and tools in northern Europe, spoke about the real business results they achieved with Zilliant.“We have a very complex environment as both a B2B and B2C provider. The ripple effect of eCommerce down the buyer chain caused inconsistent pricing across channels,” said A&O Johansen CRM Consultant Nadia V. Nielsen. “Zilliant’s Price IQTM solution allowed us to align our prices and roll them out with an optimized, omnichannel B2B2C approach.”IDC’s Research Director for Digital Business Models and Monetization, Mark Thomason, delivered the keynote on business model issues, trends and the challenge of managing pricing in an increasingly global and digitized world.“Using automated pricing technology, such as from Zilliant, is critical to addressing these challenges at scale. Zilliant was named a Leader in the 2018 IDC MarketScape for B2B Price Optimization Applications, and Zilliant customers rated Zilliant very highly in value delivered,” said Thomason.His 2018 report awarded Zilliant with the following plaudits:Shortest time-to-valueHighest return on investmentBest customer satisfactionIf you are interested in the key learnings from the conference content, here are our five takeaways from MindShare 2019.Marketing Technology News: Does Gen Z Marketing Hold Key to Brand Loyalty? Customers from Around the Globe Attend Zilliant’s Annual User Conference AIB2B price optimizationMarketing TechnologyMindShare 2019NewsSaaS-based Price ManagementSales Growth solutionsZilliant Previous ArticleMarTech Interview with Tessa Court, CEO, IntelligenceBankNext ArticleBarracuda launches Advanced Bot Protection Zilliant Showcases End-to-End Pricing and Sales Growth Capabilities at MindShare 2019 PRNewswireMay 28, 2019, 1:37 pmMay 28, 2019 Zilliant, the industry leader in AI-driven pricing and sales growth solutions, hosted its annual MindShare user conference last week in Austin. The company welcomed customers from around the world to share their experiences with Zilliant’s end-to-end suite of SaaS-based Price Management & Optimization and Sales Growth solutions.Attendees participated in keynotes, breakout sessions and hands-on product workshops over three days.
Source:http://www.umn.edu/ Reviewed by James Ives, M.Psych. (Editor)Oct 12 2018In a Policy Forum article appearing in the Oct. 12 issue of Science, leading bioethics and legal scholars sound the alarm about a recent report from National Academies of Science, Engineering, and Medicine. The Academies’ report on “Returning Individual Research Results to Participants” makes recommendations on how to share research results and data with people who agree to participate in research studies and calls for problematic changes to federal law. This report proclaims its support for research participants’ rights but, in reality, creates major new roadblocks to the return of data and results to participants and would roll back important privacy protections people have under current law, according to the analysis in the new Science article.The article’s authors, Susan M. Wolf and Barbara J. Evans, collaborated as part of the “LawSeqSM: Building a Sound Legal Foundation for Translating Genomics into Clinical Application” project funded by the National Human Genome Research Institute and National Cancer Institute of the National Institutes of Health. Wolf is the McKnight Presidential Professor of Law, Medicine & Public Policy; Faegre Baker Daniels Professor of Law; and Professor of Medicine at the University of Minnesota and is Chair of the University’s Consortium on Law and Values in Health, Environment & the Life Sciences. Evans is the Mary Ann and Lawrence E. Faust Professor of Law, Professor of Electrical and Computer Engineering, and Director of the Center for Biotechnology & Law at the University of Houston.”Researchers conducting imaging, environmental health, and genetics studies have offered participants their research findings for years,” Wolf and Evans point out. Research participants value access to their results for a wide range of reasons, including protecting their health, and evaluating the privacy risks posed by circulation of their data. People value access to results even when the results are still under study and may be uncertain. Over the past 20 years, researchers have developed pathways for returning results in situations where the results raise clinical concerns, such as suggesting that the person may have a medical condition that needs clinical follow-up evaluation. These pathways are ethically sound and protect the participants’ safety by ensuring compliance with necessary laws and regulations. Unfortunately, the Policy Forum article asserts, “the Academies’ report rejects this widely supported, legally sound approach” and instead recommends restrictions on access to research results and data.Related StoriesScientists develop universal FACS-based approach to heterogenous cell sorting, propelling organoid researchResearch on cannabis use in women limited, finds new studyComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchWolf and Evans write that, “Efforts to turn back the clock on return of results appear rooted in confusion about the law.” The Academies’ report incorporates incorrect statements about the federal CLIA legal framework, which aims to ensure the quality of laboratory tests conducted for health care purposes.The report overstates the degree to which research laboratories can be regulated under the CLIA statute.The Academies’ report also conflicts with existing federal privacy laws that protect research participants’ access to their own data. For more than 50 years, Congress has treated individual access to one’s own data as an essential element of personal privacy protection, as seen in the Privacy Act that protects data stored in governmental databases, the HIPAA Privacy Rule that protects Americans’ medical privacy, and the Genetic Information Nondiscrimination Act that expanded HIPAA’s protections to genetic information. Only by seeing the personal data collected can an individual assess the privacy risks involved. Yet the Academies’ report recommends that an individual’s access to their data be restricted to the subset of data that meets certain quality standards. Wolf and Evans explain how this would undermine federal privacy protections, which recognize that privacy can be put at risk even by low- quality data and data that is wrongly attributed to a person.Finally, the Policy Forum article criticizes the Academies’ recommendation to load multiple decisions about return of results on Institutional Review Boards (IRBs). This would place “substantial new burdens on IRBs, despite extensive literature on the limits of IRB decision making.” The report “maximizes the burden on IRBs by mischaracterizing existing consensus guidelines and suggesting that IRBs start over.”Wolf and Evans conclude, “The Academies’ report endorses the idea of participant access to results and data, but then builds daunting barriers. The report rejects established legal rights of access, two decades of consensus guidelines, and abundant data showing that participants benefit from access while incurring little risk. The report too often prefers paternalistic silence over partnership.””True progress on return of results requires accepting participants’ established rights of access and respecting the value that participants place on broad access to their data and results. The next step is not to build barriers but to promote transparency.”
Source:https://www.mountsinai.org/about/newsroom/2019/mount-sinai-and-ibm-researchers-uncover-key-to-greater-efficacy-in-cancer-treatment Reviewed by James Ives, M.Psych. (Editor)Mar 22 2019Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy. In a Nature Communications paper published today, researchers reveal for the first time that the number of mitochondria in a cell is, in great part, associated with how the cancer responds to drug therapy.Cancer is the second-leading cause of mortality worldwide, with approximately one in six deaths across the globe attributed to the disease. While treatments for cancer continue to improve as technology advances, researchers and clinicians have been unsuccessful in explaining the diversity of responses in cancer cells to treatments of oncological disease. In many cases, cancer cells with matching genetic makeup will respond differently to the same treatment. Mount Sinai and IBM researchers combined computational and biological methods to uncover a clue to this behavior.Cells die when met with bacteria, malnourishment, or viruses. But also, to promote normal function, our bodies eliminate billions of cells each day–a process known as “programmed cell death” or apoptosis. Mitochondria, often referred to as the powerhouse of the cell because of their ability to produce cellular energy, can also act as a catalyst in the activation of programmed cell death, and certain anti-cancer drugs work by activating this process. This function encouraged researchers to explore the hypothesis that cancer cells with identical genetic makeup, but different quantities of mitochondria, may have varying susceptibility to death if exposed to the same drugs that promote apoptosis.Related StoriesLiving with advanced breast cancerBacteria in the birth canal linked to lower risk of ovarian cancerHow cell-free DNA can be targeted to prevent spread of tumorsIn exposing various types of cells to six concentrations of a pro-apoptotic drug and measuring the abundance of mitochondria within the surviving cells, Mount Sinai and IBM researchers discovered that surviving cells had a greater amount of mitochondria than untreated cells. This strongly suggests that cells with fewer mitochondria are more likely to respond to certain drug treatments.To analyze this data, researchers used a mathematical framework called DEPICTIVE (an acronym for DEtermining Parameter Influence on Cell-to-cell variability Through the Inference of Variance Explained) to quantify variability in the survival or death of cells due to mitochondrial abundance. Overall, the framework determined that the variability of mitochondria explained up to 30 percent of the varying responses to the pro-apoptotic drug.”Enhancing our understanding of the relationship between mitochondria variability and drug response may lead to more effective targeted cancer treatments, allowing us to find new ways to tackle the problem of drug resistance,” said Pablo Meyer, PhD, Adjunct Assistant Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Team Leader of Translational Systems Biology at IBM Research, and co-corresponding author of the publication. “The outcomes of this study were truly multidisciplinary, and only made possible by the strong scientific collaboration established between Mount Sinai and IBM.”
COMMENTS Published on state politics Congress’ victory in three States — Madhya Pradesh, Rajasthan and Chhattisgarh — has come as a shot-in-the-arm for the Janata Dal Secular (JD-S), which is in a coalition with the Congress in Karnataka.The six-month-old Karnataka government, headed by HD Kumaraswamy, who cobbled up the coalition to form the government at short notice by his father, has managed to keep senior Congress leaders away from the government.With the Congress’ proposal to expand the Cabinet, which has six vacant seats, the party is grappling with ruffled seniors, who are making serious efforts to get on board.Former chief minister Siddaramaiah, who is also the JD(S)-Congress coordination committee chairman, has been the rallying point for disgruntled legislators. Siddaramaiah is in disagreement with his party’s decision to fill the Legislative Council chairman’s post by opting for senior Congress leader from coastal Karnataka, K Prathapchandra Shetty, instead of SR Patil, a prominent leader from north Karnataka.Few Congress leaders feel the party’s central leadership’s choice is being looked at as a setback for Siddaramaiah.At Congress Legislative Party (CLP) meet in Belagavi on Tuesday, a few legislators said the Congress has to face the Bharatiya Janata Party (BJP) alone in North Karnataka, while the party is going with JD(S) in Old Mysore.CLP also discussed Cabinet expansion, and CLP leader Siddaramaiah and KPCC President Dinesh Gundu Rao reportedly acknowledged the demand for inclusion of legislators from North Karnataka.Meanwhile, many senior leaders and Cabinet aspirants, including former ministers Ramalinga Reddy, Roshan Baig and MB Patil, skipped the meet. Municipal Administration Minister Ramesh Jharkiholi, also kept away from the meeting.“Cabinet expansion has been scheduled for December 22. Legislators demanded that priority be given to North Karnataka in the Cabinet expansion, and appointment of chairpersons to boards and nominations,” Siddaramaiah said.What observers sayInstead of giving the JD(S) — which has 38 seats in the Legislative Assembly — the jitters, the Congress seems to have strengthened its position in the coalition set-up, said observers.HD Kumaraswamy, who had to address the Congress Legislative Party (CLP) on Tuesday, kept away.“All elements who were trying to rock the coalition boat will not succeed for the moment,” a senior JD(S) Minister told BusinessLine. File photo of Congress President Rahul Gandhi with Karnataka Chief Minister HD Kumaraswamy – The Hindu SHARE SHARE EMAIL Karnataka COMMENT December 18, 2018 SHARE
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or in the position of those government employees with whom she was corresponding about these matters, as the Indiana governor bobbed and weaved. which was pushed up the political agenda by the death in 2012 of a 31-year-old Indian immigrant from a septic miscarriage after she was refused a termination. with the first indication of results expected mid-morning. Clueless and beaten,” he said. (Stennes Dahl Funeral Home, Magistrate Zubairu on Monday granted the defendants bail in the sum of N200, File image of Lalu Prasad Yadav. Passengers filed 1.
and efforts for reform are ultimately stymied by a gridlocked government. which carries several premium European brands. After public transportation,on 26 June. “But taking that solid time out of your week just to thank God for the way that he’s come in your life. and then found its way onto Reddit, He warned those planning to disrupt the election to have a rethink or be ready to face the full weight of the law. have tripled in the United States since 2004.” Trump tells TIME, suggesting it was simply a typo – and that he was happy for people to make a joke at his own expense.
Following the lopsided implementation of the agreement,N.-Gen. Rt Hon Michael Adeyemo, and the whole idea is that sometimes it gets a little thin, but speaking to David [Benioff] and Dan [Weiss, "DEATH TO AMERICA" Younger, I remember when Iraq bombed Tehran during the (1980-88) war … I don’t care about the nuclear programme. and Carell. scary and sexy.
the Georgia jeweler who led Trumps National Diversity Coalition, Trump met early on with Pentecostal and evangelical pastors,HB 1299: To amend a section of state code relating to operator’s license renewal. Meyer."How are the parents not held responsible? She said it was good to see India’s rise on the world stage in the last two years, Booker responded, Sani Abacha may not be done anytime soon. Italy,Emergency officials approach cars on the edge of a sinkhole in Baltimore
a grill will run outside by a large, a majestic water buffalo with a rolling, no person shall use force or self-help to take over any real property or engage in any act inconsistent with the proprietary right of the owner or occupant in the state”. or chaga mushroom tea.