Map of DhakaAt least six people were killed and several others injured in three separate road accidents in Dhaka city, Kushtia and Narshingdi districts on Tuesday morning.An on-duty police constable was killed in a road accident near Gabtali bus terminal in the capital around 7:00am.The deceased is Abdul Mazid, 35, a resident of Naogaon district.Witnesses said Abdul Mazid died around 9:00am while undergoing treatment at the Dhaka Medical College Hospital’s emergency unit.Traffic police sergeant Monir Hossain said on-duty Mazid was injured as a truck hit him in Gabtali area.His body is kept in DMCH morgue.Map of NarsingdiIn Narsingdi, according to news agency UNB, a primary school teacher and a young man were killed in a head-on collision between a truck and CNG-run auto-rickshaw on Narsingdi-Raipura road in Sadar upazila on Tuesday morning.The deceased are Fatema Tuz Johora, 24, a teacher of Panchchabati Primary School and a resident of Puranpara area in district town and Bashir Miah, 26, of the area.The accident took place around 8:30am when a Raipura-bound CNG-run auto-rickshaw collided head-on with a truck from opposite direction, leaving Fatema dead on the spot and four others critically injured, said Md Muzaffar Ahmed, officer-in-charge of Sadar Police Station.Locals rescued the injured and sent them to Narsingdi Sadar Hospital from where Bashir was referred to Dhaka Medical College Hospital as his condition was deteriorating.Bashir succumbed to his injuries on way to DMCH, the OC added.Map of KushtiaIn Kushtia, three people were killed and several others were injured as bus knocked down a battery-run auto-vehicle (locally known easy-bike) in Sadar upazila of the district around 9:45am.Identities of the deceased could not be known immediately.Police and witnesses said a bus of SB Paribahan hit the battery-run vehicle after one of its tyres exploded, leaving three people dead on the spot.The injured were admitted to Kushtia General Hospital, the witnesses added.Islamic University police station officer-in-charge Ratan Sheikh said identities of the deceased could not be known as yet.
Natore police superintendent Biplob Bijoy Talukder speaking with reporters after conducting a drive where four suspected activists of JMB surrendered to the law enforcers in Natore. Photo: Muktar HossainPolice in a drive arrested four suspected activists of banned militant outfit Jama’atul Mujahideen Bangladesh (JMB) from Dighapatia, on the outskirts of Natore town, early Tuesday, reports news agency UNB.The arrestees are—Anisur Rahman Anis, a resident of Arkandi village in Singra upazila, Shafikul Islam and Fazlur Rahman, residents of Chapapukur village in Bagatipara upazila and Jakir Hossian, a resident of Kholabaria village in Naldanga upazila.Acting on a tip-off, a police team cordoned off a house adjacent to the Uttara Gonobhaban around 3:00am and started operation at the house from 5:30am and asked the insiders to surrender to the law enforcers after nine rounds of firing, claimed police.After one hour, the four suspected activists of JMB surrendered to the law enforcers.Police, later, recovered five hand bombs, petrol, a laptop, one motorcycle and books searching the house.Details will be come to light after interrogation of the arrestees and investigation, said Natore police superintendent Biplob Bijoy Talukder.
Jatiya Oikya Front leader Kamal Hossain speaking at a programme organised by Jatiya Samajtantrik Dal (JSD-Rob) at Jatiya Press Club on Friday. Photo: Prothom AloStating that the government is in trouble, Jatiya Oikya Front convener Kamal Hossain on Friday warned that it will not be able to run the country for long with ‘falsehood’, reports UNB.”This government is in trouble as it’s running the country staying in power without (proper) election. It’s now making various promises which are very difficult to fulfill,” Kamal said while speaking at a discussion arranged by Jatiya Samajtantrik Dal (JSD-Rob) marking the historic first flag hoisting day. “What happened on the night of 29 December? Was it a free, fair and neutral election? What was it actually? I would like to say it’s difficult to run a country of 160 million people based on falsehood and wrong information. It can’t be done, ” said the noted lawyer.Kamal, also the president of Gono Forum, said there is no disagreement among the people over some basic issues and they all believe that they are the owners of the country.”Nobody wants a monarchy here and nobody wants to see any king or queen here. Bengalee is such a nation which will never accept any king or queen in the country.”He said people now feel some sort of helplessness as the government is not showing respect for them as the owners of the country.”But no one should feel helpless when there are 17 crore people who can play the role of owners of the country. Those who think they have become the country’s owners dividing people they are making a mistake.”The Oikya Front chief said the country’s people ousted the autocratic rulers, including HM Ershad, through their united efforts in the past. “We’ll also get united now and bring the country under our occupation through a democratic and constitutional process.”Mentioning that the country was liberated based on unity of people; he said people’s ownership of the country will also be restored now based on unison among them.Speaking at the programme, JSD president Abdur Rob recalled the memory of hoisting the country’s flag for the first time on 2 March, 1971.Describing the current government as autocratic one, he said it will not leave power easily unless people come up with a united and strong resistance against it.Nagorik Oikya convener Mahmudur Rahman Manna said Awami League has snatched people’s voting rights on 29 December by using the state machinery.”The Awami League which liberated the country under the leadership of Bangabandhu Sheikh Mujiubur Rahman doesn’t exist in the country. The current Awami League is an associate body of police league.”He said people on Thursday sent out a message to the government that they do not want any election under it by not going to polling stations to cast their votes in the by-polls to Dhaka North City Corporation’s mayoral post.
Listen at WEAA Live Stream: http://amber.streamguys.com.4020/live.m3uMonday’s national politics discussion with our regular commentators Catalina Byrd and Sean Breeze, including Donald Trump’s attack on Bill Clinton and Isis using Trump’s vitriol to recruit for their terror missions. Also, the legacy of Dr. Frances Cress Welsing, author of the seminal Isis Papers, who died over the weekend, with Dr. Ray Winbush, the director of Morgan State University’s Institute for Urban Research and Kevin Washington, president of the Association of Black Psychiatrists.These stories and more coming up this evening on AFRO’s First Edition with Sean Yoes.
LAS VEGAS, Nev. – Sam Fuehring’s layup with three seconds remaining gave No. 5 Louisville a 58-56 win over No. 19 Arizona State on Friday afternoon at the South Point Shootout in Las Vegas, Nev.Louisville (4-0) entered the fourth quarter trailing 41-37, but outscored the Sun Devils 21-15 the rest of the way.The Cardinals trailed 45-41 with 8:17 to go and then went on an 8-0 run to take a 49-45 lead midway through the fourth. They held the lead until Arizona State’s Sophia Elenga made both free throws to tie the game at 56-56 with 11 seconds to go. That set the stage for the game-winner as Dana Evans drove the lane and found Fuehring underneath for the layup with three seconds remaining. Arica Carter then stole the inbounds pass to seal the victory.Fuehring led the way for the Cards with 18 points and nine rebounds. She finished 7-13 from the floor and 4-5 from the free throw line, making some crucial free throws down the stretch.Asia Durr added 14 points and three assists, while Dana Evans finished with 11 points and six assists. Evans scored eight of her 11 points in the fourth quarter.UP NEXTLouisville: The Cardinals conclude play in Las Vegas against Hartford tomorrow at 3 p.m. ET.For the latest on Louisville women’s basketball, visit GoCards.com, follow the team’s Twitter account at @UofLWBB or on Facebook at facebook.com/UofLWBB.Print Friendly Version Story Links Box Score (PDF)
An international team of researchers working in a lab at Harvard University has taken a bold step towards the development of a bacteria with a completely rewritten genome. They describe their work in a paper published in the journal Science and the reasons they believe the ultimate results will be safe for use in the real world. Science correspondent John Bohannon offers an In Depth piece on the work done by the team in the same issue and further discusses safety concerns tied to the new technology. More information: N. Ostrov et al. Design, synthesis, and testing toward a 57-codon genome, Science (2016). DOI: 10.1126/science.aaf3639 Citation: Researchers design and partially assemble a synthetic Escherichia coli genome (2016, August 19) retrieved 18 August 2019 from https://phys.org/news/2016-08-partially-synthetic-escherichia-coli-genome.html © 2016 Phys.org Journal information: Science Scientists would like to be able to modify the genomes of creatures because they believe such creatures could offer benefits to us humans that are not available naturally. One example would be changing the genome of a certain type of bacteria to make it immune to viral attacks—this would be important because we humans use bacteria in a variety of applications and viruses tend to cause problems in many of them.In this new effort, the researchers took a step into the future by eliminating redundant codons—triplets that represent four-letter DNA alphabet clusters—from the DNA of an E. coli bacterium, opening the door to the possibility of inserting new coding that would allow for the creation of new types of amino acids. To achieve this feat, they used machines to synthesize stretches of the genome (in its recoded form) and then inserted the chunks they had created into the genome of a living E. coli bacterium. The team managed to eliminate seven of the bacterium’s 64 natural codons in the chunks they inserted and were able to test approximately 63 percent of them. They report that doing so resulted in very few interruptions to natural functions, which suggests the technique may prove a viable means for creating an entirely new genome for a given creature. Perhaps more impressive is the possibility of creating new types of codons to replace the redundancies that were removed, which could, for example, endow bacteria or other creatures with new capabilities, such as producing amino acids that could fight off new types of viruses.The good news must be tempered with the bad of course as such research is likely to stir fear in people who wonder what havoc might ensue should such bacteria make their way into the real world. The team has added a fail-safe, of course, and others will no doubt be developed, but because we humans are prone to error, no such fail-safe could ever be deemed 100 percent safe. Explore further Using CRISPR as a recording device Escherichia coli. Credit: Rocky Mountain Laboratories, NIAID, NIH This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Share LAS VEGAS — Radisson has signed the award-winning Treasure Island – TI Hotel & Casino in Las Vegas to its portfolio of hotels, marking the company’s first property on the famous Las Vegas Strip.Featuring nearly 3,000 rooms, the resort will officially join the Radisson system later this year as Treasure Island – TI Hotel & Casino, a Radisson Hotel. Guests will be able to book a stay by late 2019, and Radisson Rewards members will be able to earn and redeem points in 2020.The hotel is located within walking distance of the Sands Expo and is connected by pedestrian bridges leading to Fashion Show shopping mall and Grand Canal Shoppes. It’s home to several upscale and casual dining choices, a spa and world-class entertainment, including Mystère by Cirque du Soleil.As part of the agreement, TI will retain its current branding and exterior signage.“TI is a true resort destination in a one-of-a-kind city, and one we’ve been keen to offer to our loyal guests for quite some time,” said Ken Greene, president, Americas, Radisson Hotel Group. “Treasure Island is home to one of the best locations and values in Las Vegas, and we’re honoured to welcome such a well-known resort and casino to our growing portfolio.” Friday, July 26, 2019 Las Vegas’ Treasure Island to rebrand under Radisson flag Posted by Tags: Las Vegas, Radisson Hotel Group, TH Hotel & Casino, Treasure Island << Previous PostNext Post >> Travelweek Group
Welcome to Starters Orders. Our daily midday update from the trading room at Star Sports with our key market movers for the day across all sports.Wednesday 18 DecemberPlenty of support for the Henderson horses today. His day started well with Dawalan winning at Newbury.12.40 NewburyMidnight Prayer 2/1 > 7/412.50 LudlowBenbens 9/4 > 7/41.10 NewburyJossies Hill 6/4 > 5/42.15 NewburyHadrian’s Approach 3/1 > 7/4 (inc R4)2.45 NewburyTistory 11/8 rock solid4.20 KemptonMiguel Grau 3/1 > 5/2FOOTBALLTottenham well supported tonight against West Ham despite no AVBWhat’s your view?CALL STAR SPORTS ON 08000 521 321
Legal Marijuana Illinois Is Now the 11th State to Legalize Adult-Use Marijuana — $2B Market Projected –shares Green Entrepreneur Podcast Listen Now Image credit: Aurimas Adomavicius | Getty Images June 26, 2019 Jeffrey L. Smith Illinois Gov. J.B. Pritzker on Tuesday signed a recreational marijuana legalization bill into law, paving the way for the creation of a potential $2 billion market with strong business opportunities.With the signature, Illinois becomes the first state in the country to legalize retail sales through its Legislature and the 11th overall to approve adult use. Pritzker’s signature was considered a fait accompli, since he had pushed legalization and announced his intention to sign the bill as soon as the legislature approved it in late May.“We’re also creating a $30 million low-interest loan program to create opportunity for entrepreneurs in the communities that deserve it the most (from the war on drugs),” Pritzker tweeted Tuesday. Experts believe Illinois’ social equity program, if successful, could become a blueprint for other MJ programs across the country.Marijuana Business Daily projects that the Illinois recreational program, which will launch Jan. 1, 2020, could generate up to $2.5 billion a year depending in part on how many tourists buy MJ products. Illinois is the second state in the Midwest to legalize recreational marijuana. Michigan voters passed a referendum last November that legalized recreational marijuana.The following are key business aspects to the Illinois measure:Existing medical marijuana license holders can begin adult-use sales on Jan. 1, 2020. There currently are 55 licensed dispensaries in the state.Illinois will award permits for up to 75 stores by May 1, 2020 as well as 40 processors and 40 craft growers by July 1, 2020.The measure calls for the state to issue licenses for an additional 110 stores, 60 craft growers and 60 processors in December 2021.Municipalities can prohibit recreational cannabis, although Chicago is expected to be open.Applicants that fall under social equity provisions receive additional points and potential financial resources and support such as low-interest loans, grants, training assistance and mentoring. Next Article This story originally appeared on Marijuana Business Daily Add to Queue Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. 2 min read The legalization measure contains social equity provisions activists believe could be a national model.
2019 Entrepreneur 360 List Contributor Thomas Smale Conferences Add to Queue Next Article Opinions expressed by Entrepreneur contributors are their own. Founder of FE International January 27, 2016 11 Ecommerce Conferences You Should Consider for 2016 Your business can demand major time — especially when you’re first getting set up or you’re in the midst of growing and scaling. But if you burn the candle on both ends, or sacrifice your health and relationships, your efforts are all for naught. Sometimes, it’s necessary to step away from your business to gain perspective.Related: 7 Conferences for Entrepreneurs Under 30Conferences can be a great way to take a break. Traveling to them, participating in their sessions and workshops and networking with other business owners can help you get out of a rut if you’re in one, think more strategically about your business and be in touch with people who can help you.Not that you need to go to every conference that’s out there. What’s important is to take time to recharge, and return to your business ready to tackle new challenges. As a business owner, I’ve also found speaking to be an effective way to grow my business. So, with those things in mind, here is a list, compiled by my team, of 11 of our favorite ecommerce conferences.1. The 10x E-Commerce EventWith over 25 speakers and 18 sessions, the 2016 10x E-Commerce Event this February will focus entirely on tactics you can use to drive more qualified traffic to your site, then convert these people into buying customers. You will learn about the ins and outs of conversion optimization, customer retention, A/B testing, marketing automation and much more.This year’s keynote speakers are Ashlee Vance, Paco Underhill and Timothy Seward. The summit will be held at the Renaissance Orlando at SeaWorld, February 10-12.2. eTail WesteTail West will be held in Palm Springs, California, February 22-25. You’ll have the opportunity to learn about a variety of topics like content marketing, mobile engagement, data and various pain points and areas that affect your business. This year’s keynote speakers include Ron Boire, Kelly McGann, Eric Anderson, Eoin Comerford, Jen Cotter and David Katz.Other eTail events will be held throughout the year at various locations:eTail Germany will be held in Berlin March 8-10.eTail Canada will be in Toronto, Ontario, May 16-19.eTail Europe happens in London, England, June 21-23.eTail East will be in Boston, August 15-18.3. eCommerceFuel LiveeCommerceFuel Live is made up of an exclusive group of six-and-seven-figure independent store owners. This year’s keynote speakers include Miracle Wanzo, Paul Lepa and David Heacock. The event will be held at The Gaylord Opryland in Nashville, Tenn., and will feature world-class musical entertainment. This three-day conference will happen October 7-10.4. MivaconAre you looking to learn about industry best practices, SEO, conversion optimization, content marketing, international ecommerce, trends in ecommerce and other related topics? The beginner-friendly Mivacon will be held in San Diego, March 9-11. The conference schedule has yet to be announced in full, but Rick Wilson will be one of the keynote speakers. 5. Sellers’ Conference For Online EntrepreneursThe Sellers’ Conference for Online Entrepreneurs — or SCOE — will be held in Philadelphia, March 23-25. The speaker roster includes Emily Murray, Rob Wray, Ashvin Kumar, Chris McCabe and others. At SCOE, you will learn about tools and trends in improving your online selling, driving more sales, optimizing your product and service offerings, expanding globally and more. The main focus is on sellers who use Amazon, eBay, Sears, Etsy and the like.Related: Conferences Are Good for Networking but Great for Marketing6. Imagine CommerceImagine Commerce is being held in Las Vegas, April 11-13. A premier Magento commerce conference, Imagine brings together more than 2,500 merchants, developers, partners and experts from more than 45 countries worldwide. Past years’ speakers have included keynotes from Malcolm Gladwell and Steve Wynn and sessions featuring brands and retailers like Toys R Us, Rebecca Minkoff, 3M, Kendra Scott, Zoetis and others.7. Internet Retailer Conference + ExhibitionThe Internet Retailer Conference + Exhibition — or IRCE — offers access to some of the leading industry experts and a one-of-a-kind exhibit hall displaying 600 of the latest solution providers. The 2016 speaker roster is comprised of Raj Aggarwal, Kelli Agnich, Gene Alvarez, Adam Audette, Rick Backus, Amy Ballantyne Rapawy and others.8. Sellers SummitSellers Summit offers an intense “workshop” experience focusing on up-to-date actionable insights — instead of feel-good stories — that entrepreneurs can use to grow their revenues. Speakers include event host Steve Chou, Scott Voelker, Greg Mercer, Toni Anderson, Andrew Youderian, Eric Siu, Spencer Haws, Andreea Ayers, Autumn Wyda, and others. The Sellers Summit takes place in Miami, May 19-21.9. Freedom Fast Lane LiveDetails are as of yet forthcoming for the 2016 Freedom Fast Lane Live conference, but it’s sure to be an incredible experience. Speaker Ryan Moran, for instance, is a true ecommerce expert. At F2L2, you will have the opportunity to meet, connect with and learn from industry leaders to stretch your mindset and be challenged to think beyond what you believe is possible in your business. My team at FE International loved the 2015 event. 10. Retail GlobalRetail Global occurs September 20-22 in Las Vegas. Its primary area of focus will be international commerce. Attendees will have the opportunity to learn from speakers from across the world and build a network of trusted contacts. This year’s speakers have yet to be announced.11. SHOPTALKFocusing on tech-based disruption in ecommerce, SHOPTALK will be held in Las Vegas May 15-18. Its wide range of speakers will include Casey Carl, Daphne Carmeli, Tracy Dinunzio, Ron Johnson, Tim Kendall, Katrina Lake, Raghav Lal, Brian Lee, Marc Lore, Julie Wainright, Janie Yu and others. At SHOPTALK, you can expect to learn the latest trends in engaging consumers.Final thoughtsAs a business owner, you’ll find that the most important investment you can make is in yourself and the future of your business. Conferences give you the chance to learn, grow and connect with others who are successful in their respective fields.Certainly, there are lots of great events out there; and it can be hard to know which to choose. But, ultimately, you will benefit from the experience, no matter what. It isn’t all about what you learn, but rather the decisions you make coming out of a conference, and the new connections you make.Related: 8 Tips to Be an Awesome Networker at Conferences 6 min read –shares The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »
Zilliant’s Annual MindShare 2019 Showcases End-to-End Pricing and Sales Growth Capabilities “It’s an honor to host such a wide array of innovators – longtime customers, companies evaluating Zilliant technology, strategic partners, industry experts – in our hometown,” said Zilliant CEO Greg Peters. “The steep challenges faced by B2B organizations every day are being met head on by our customers, who have harnessed the power of their data and are using Zilliant’s intelligent technology to their advantage.”MindShare focused on distributors, manufacturers and service providers dealing with a rapidly changing business landscape across various industries, with topics such as:B2B eCommerce disruptionAdopting a Pricing Center of ExcellenceDigitization and optimizationPricing modes and methodsDistributor / manufacturer partnershipsOmnichannel pricingMarketing Technology News: Information Builders’ WebFOCUS Named a FrontRunner in Business Intelligence in Fourth Consecutive Report“When disruptors, like Amazon, are duplicating parts of your value proposition, you need to duplicate parts of theirs,” said Ian Heller, President & COO of Modern Distribution Management in his message to attendees. “Traditional B2B companies must scale with technology and become more comfortable doing business online, while offering services that are hard for disruptors to digitize.”A common theme was Zilliant’s comprehensive ability to solve pricing and sales problems big and small, from price list management to advanced, actionable AI-driven pricing and sales guidance.“We wanted to create a data-driven culture as part of our digital transformation journey,” said Mike Eppes, Managing VP of Parts at Rush Enterprises. “Zilliant has become our data science backbone for our parts operations, serving as the nexus for many of our IT systems, from CRM to eCommerce. As a result of using Zilliant’s solutions, we are achieving higher revenue and profits and are better able to anticipate our customers’ needs.”Marketing Technology News: AI-Driven Weather Data: New to Some, But It Has Been Driving CustomWeather’s Success for YearsMindShare featured interactive deep dive sessions led by veteran Zilliant customers. A&O Johansen, a major distributor of technical installation materials and tools in northern Europe, spoke about the real business results they achieved with Zilliant.“We have a very complex environment as both a B2B and B2C provider. The ripple effect of eCommerce down the buyer chain caused inconsistent pricing across channels,” said A&O Johansen CRM Consultant Nadia V. Nielsen. “Zilliant’s Price IQTM solution allowed us to align our prices and roll them out with an optimized, omnichannel B2B2C approach.”IDC’s Research Director for Digital Business Models and Monetization, Mark Thomason, delivered the keynote on business model issues, trends and the challenge of managing pricing in an increasingly global and digitized world.“Using automated pricing technology, such as from Zilliant, is critical to addressing these challenges at scale. Zilliant was named a Leader in the 2018 IDC MarketScape for B2B Price Optimization Applications, and Zilliant customers rated Zilliant very highly in value delivered,” said Thomason.His 2018 report awarded Zilliant with the following plaudits:Shortest time-to-valueHighest return on investmentBest customer satisfactionIf you are interested in the key learnings from the conference content, here are our five takeaways from MindShare 2019.Marketing Technology News: Does Gen Z Marketing Hold Key to Brand Loyalty? Customers from Around the Globe Attend Zilliant’s Annual User Conference AIB2B price optimizationMarketing TechnologyMindShare 2019NewsSaaS-based Price ManagementSales Growth solutionsZilliant Previous ArticleMarTech Interview with Tessa Court, CEO, IntelligenceBankNext ArticleBarracuda launches Advanced Bot Protection Zilliant Showcases End-to-End Pricing and Sales Growth Capabilities at MindShare 2019 PRNewswireMay 28, 2019, 1:37 pmMay 28, 2019 Zilliant, the industry leader in AI-driven pricing and sales growth solutions, hosted its annual MindShare user conference last week in Austin. The company welcomed customers from around the world to share their experiences with Zilliant’s end-to-end suite of SaaS-based Price Management & Optimization and Sales Growth solutions.Attendees participated in keynotes, breakout sessions and hands-on product workshops over three days.
Source:https://www.hptn.org/news-and-events/press-releases/hptn-075-study-demonstrates-high-rate-of-hiv-infection-among-african Reviewed by James Ives, M.Psych. (Editor)Oct 24 2018Researchers from the HIV Prevention Trials Network (HPTN) today presented results from the HPTN 075 Study at the HIV Research for Prevention (HIVR4P) conference in Madrid, Spain. The study evaluated the feasibility of HIV prevention research among men who have sex with men (MSM) and transgender women (TGW) in three countries in sub-Saharan Africa. Findings from the study showed participants were at an alarming risk for getting HIV. The incidence among study participants was substantially higher than the estimated incidence among heterosexual men and women in the general population in the same countries.”Several studies have shown the burden of HIV is quite high among MSM and TGW, but little is known about the rate of new infections, or HIV incidence, among these groups in sub-Saharan Africa,” said Theo Sandfort, PhD, HPTN 075 protocol chair and research scientist, HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University in New York. “The exceptionally high HIV incidence we found indicates an urgent need for increased access to HIV prevention approaches that consider all the factors that put this vulnerable population at such high risk.”Related StoriesHIV therapy leaves unrepaired holes in the immune system’s wall of defenseHIV DNA persists in spinal fluid despite treatment, linked to cognitive impairmentHIV persists in spinal fluid even after long-term treatment and is linked to cognitive deficitsA total of 401 MSM and TGW, regardless of HIV infection status, were enrolled at four sites in Kenya, Malawi and South Africa. Each participant was followed for 12 months, during which five study visits were conducted. These visits included interviewing participants about behaviors that may put them at risk for HIV infection, medical examinations and collection of blood samples. Of the 401 enrolled, 329 were HIV-negative at the time of enrollment. By the end of the study, 21 of them had become infected with HIV. This translates to an overall incidence rate of 6.96 per 100 person-years. Incidence rates differed substantially by study site: Malawi: 1.3; Kenya: 3.75; Soweto, South Africa: 8.97; and Cape Town, South Africa: 14.44.”HPTN 075 provides compelling findings that indicate an urgent need for further HIV prevention studies for men who have sex with men and transgender women in sub-Saharan Africa,” said Wafaa El-Sadr MD, MPH, MPA, HPTN co-principal investigator and professor of epidemiology and medicine at Columbia University in New York. “These studies must examine the realities in which these groups exist and develop integrated intervention strategies that are effective and feasible.””MSM and TGW in sub-Saharan Africa face distinct structural barriers to accessing HIV prevention and treatment,” said Myron Cohen, MD, HPTN co-principal investigator and director of the University of North Carolina at Chapel Hill Institute for Global Health and Infectious Diseases in Chapel Hill, NC. “The HPTN is poised to tackle these barriers as we prioritize this population in our prevention agenda.”
Source:http://www.bmc.org/ Reviewed by James Ives, M.Psych. (Editor)Mar 11 2019Compared to experimental studies that require complex infrastructures such as laboratories or clinical trials at multiple centers, studies using a longitudinal cohort (an observational research method in which data is gathered for the same participants repeatedly over a period of time) could be a good alternative for investigators as they begin their early research careers.”The Framingham Heart Study (FHS) is an excellent example of a database to initiate investigations and generate questions that could be followed later by experimental studies,” explains Hugo J. Aparicio, MD, MPH, assistant professor of neurology at Boston University School of Medicine, in a perspective article in the journal Stroke.Related StoriesOlympus launches next-generation X Line objectives for clinical, research applicationsTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTBridging the Gaps to Advance Research in the Cannabis IndustryFunded by the National Heart, Lung and Blood Institute of the National Institutes of Health, FHS began in 1948, as a database of thousands of participants from Framingham, Mass., who volunteered and shared their medical and personal data to advance clinical knowledge. Over the decades, FHS has helped answer key questions related to cardiovascular and neurological diseases. More than 15,000 participants have been included in FHS studies resulting in nearly 3,700 published articles using the data.According to Aparicio, data from longitudinal cohort studies often contain more detail than administrative datasets, which can result in research with higher quality data that can lead to higher impact publications. In addition, ongoing studies often have well-established research teams and senior investigators with extensive experience. “Access to high-quality data, mentorship and training in the research process are critical for launching a career in clinical research.”However, he cautions that using longitudinal cohort studies does pose some challenges and limitations, including: the way that data is collected makes interpretation of results critical and requires careful insight; loss to follow up when patients drop out of the studies and the difficulty of analyzing rare conditions caused by limited number of participants compared to the total general population.Regardless, Aparicio hopes his perspective article stimulates early career investigators to take advantage of these resources. “Beyond opportunities to publish, joining a research team at a cohort study can open doors for mentorship, expand research skills and help focus and refine your research path.”
Source:https://www.mountsinai.org/about/newsroom/2019/mount-sinai-and-ibm-researchers-uncover-key-to-greater-efficacy-in-cancer-treatment Reviewed by James Ives, M.Psych. (Editor)Mar 22 2019Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy. In a Nature Communications paper published today, researchers reveal for the first time that the number of mitochondria in a cell is, in great part, associated with how the cancer responds to drug therapy.Cancer is the second-leading cause of mortality worldwide, with approximately one in six deaths across the globe attributed to the disease. While treatments for cancer continue to improve as technology advances, researchers and clinicians have been unsuccessful in explaining the diversity of responses in cancer cells to treatments of oncological disease. In many cases, cancer cells with matching genetic makeup will respond differently to the same treatment. Mount Sinai and IBM researchers combined computational and biological methods to uncover a clue to this behavior.Cells die when met with bacteria, malnourishment, or viruses. But also, to promote normal function, our bodies eliminate billions of cells each day–a process known as “programmed cell death” or apoptosis. Mitochondria, often referred to as the powerhouse of the cell because of their ability to produce cellular energy, can also act as a catalyst in the activation of programmed cell death, and certain anti-cancer drugs work by activating this process. This function encouraged researchers to explore the hypothesis that cancer cells with identical genetic makeup, but different quantities of mitochondria, may have varying susceptibility to death if exposed to the same drugs that promote apoptosis.Related StoriesLiving with advanced breast cancerBacteria in the birth canal linked to lower risk of ovarian cancerHow cell-free DNA can be targeted to prevent spread of tumorsIn exposing various types of cells to six concentrations of a pro-apoptotic drug and measuring the abundance of mitochondria within the surviving cells, Mount Sinai and IBM researchers discovered that surviving cells had a greater amount of mitochondria than untreated cells. This strongly suggests that cells with fewer mitochondria are more likely to respond to certain drug treatments.To analyze this data, researchers used a mathematical framework called DEPICTIVE (an acronym for DEtermining Parameter Influence on Cell-to-cell variability Through the Inference of Variance Explained) to quantify variability in the survival or death of cells due to mitochondrial abundance. Overall, the framework determined that the variability of mitochondria explained up to 30 percent of the varying responses to the pro-apoptotic drug.”Enhancing our understanding of the relationship between mitochondria variability and drug response may lead to more effective targeted cancer treatments, allowing us to find new ways to tackle the problem of drug resistance,” said Pablo Meyer, PhD, Adjunct Assistant Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Team Leader of Translational Systems Biology at IBM Research, and co-corresponding author of the publication. “The outcomes of this study were truly multidisciplinary, and only made possible by the strong scientific collaboration established between Mount Sinai and IBM.”
Reviewed by Kate Anderton, B.Sc. (Editor)Apr 9 2019The U.S. Food and Drug Administration today approved Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture). These are women with a history of osteoporotic fracture or multiple risk factors for fracture, or those who have failed or are intolerant to other osteoporosis therapies.More than 10 million people in the U.S. have osteoporosis, which is most common in women who have gone through menopause. People with osteoporosis have weakened bones that are more likely to fracture.”Today’s approval provides women with postmenopausal osteoporosis who are at high risk of fracture with a new treatment that will reduce this risk,” said Hylton V. Joffe, M.D, M.M.Sc., director of the Center for Drug Evaluation and Research’s Division of Bone, Reproductive and Urologic Products. “But Evenity may increase the risk of heart attack, stroke and cardiovascular death so it’s important to carefully select patients for this therapy, which includes avoiding use in patients who have had a heart attack or stroke within the previous year.”Evenity is a monoclonal antibody that blocks the effects of the protein sclerostin and works mainly by increasing new bone formation. One dose of Evenity consists of two injections, one immediately following the other, given once a month by a health care professional. The bone forming effect of Evenity wanes after 12 doses so more than 12 doses should not be used. If osteoporosis therapy is needed after the 12 doses, patients should begin an osteoporosis treatment that reduces bone breakdown.The safety and efficacy of Evenity were demonstrated in two clinical trials involving a total of more than 11,000 women with postmenopausal osteoporosis. In the first trial, one year of treatment with Evenity lowered the risk of a new fracture in the spine (vertebral fracture) by 73% compared to placebo. This benefit was maintained over the second year of the trial when Evenity was followed by one year of denosumab (another osteoporosis therapy) compared to placebo followed by denosumab. In the second trial, one year of treatment with Evenity followed by one year of alendronate (another osteoporosis therapy) reduced the risk of a new vertebral fracture by 50% compared to two years of alendronate alone. Evenity followed by alendronate also reduced the risk of fractures in other bones (nonvertebral fractures) compared to alendronate alone.Related StoriesStudy discusses beneficial effects of antibody therapy that targets sclerostinAn injection of nanoparticles for spinal cord injuriesWomen exposed to common antibacterial more likely to develop osteoporosisEvenity increased the risk of cardiovascular death, heart attack and stroke in the alendronate trial, but not in the placebo trial. Therefore, Evenity contains a boxed warning on its labeling stating that it may increase the risk of heart attack, stroke and cardiovascular death and should not be used in patients who have had a heart attack or stroke within the previous year. Health care professionals should also consider whether the benefits of Evenity outweigh its risks in those with other risk factors for heart disease and should discontinue Evenity in any patient who experiences a heart attack or stroke during treatment.Common side effects of Evenity included joint pain and headache. Injection site reactions were also observed.The FDA granted the approval of Evenity to Amgen.Source: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm635653.htm
Hong Kong shares linked to troubled Chinese conglomerate Wanda surged 52 percent Tuesday after the company announced a $5.4-billion stake sale and retail tie-up with investors including internet giant Tencent. Explore further It is the latest move by Wanda boss Wang Jianlin—once China’s richest man—to sell off parts of his real estate empire following a rapid diversification that left the firm mired in debt and under the scrutiny of government regulators.Wanda Group will sell 14 percent of Wanda Commercial Properties, China’s largest shopping mall operator and the group’s flagship, for 34 billion yuan ($5.4 billion).Led by Tencent, the buyers will include leading retailer Suning, ecommerce company JD.com, and real estate giant Sunac, Wanda said in a statement late Monday.The hook-up with the likes of Tencent and JD.com signals a change in strategy for Wanda—moving away from property development and wading into the rapidly evolving Chinese retail sector.The news sent the Hong Kong shares of its hospitality arm Wanda Hotels—its main publicly-listed entity—skyrocketing.The stock leapt 52 percent early Tuesday before falling back to HK$1.72, up 27 percent, just before noon.The group said Wanda Commercial Properties “will stop engaging in property development and will transform into a company solely focused on commercial management.” Wanda would look to take the company—which will be rechristened Wanda Commercial Management—public “as soon as possible.” Wang had delisted Wanda Commercial from the Hong Kong exchange in 2016 due to low valuations.The conglomerate’s statement said Wanda Commercial would combine its “vast shopping mall assets” with the retail and internet power of Tencent, Suning, and JD.com, to “jointly build a ‘new consumption’ model in China that will integrate both online and offline services.””This represents one of the world’s largest single strategic investments between Internet companies and brick-and-mortar commercial giants,” Wanda said.Those plans would likely put them in competition with Alibaba, the Chinese e-commerce titan that is pressing ahead with plans to extend its influence in the bricks-and-mortar sphere. Wanda Group had diversified rapidly in recent years from commercial property into entertainment, theme parks, sports and other sectors, but is now squeezed by debts run up through a series of massive, high-profile foreign acquisitions.Wanda and other Chinese conglomerates that expanded quickly overseas have come under official scrutiny as Beijing clamps down on capital flight and skyrocketing debt.Wanda has been selling off assets after reports said authorities advised banks to avoid loans to the group.Among other divestments, last year it sold dozens of hotels and other projects to Sunac and real estate firm R&F Properties for around $10 billion. © 2018 AFP Chinese e-commerce rivals challenge Alibaba (Update) Wang Jianlin, once China’s richest man, has been selling off parts of his real estate empire following a rapid diversification that left the firm mired in debt Citation: Wanda stock skyrockets after $5.4bn Tencent tie-up (2018, January 30) retrieved 18 July 2019 from https://phys.org/news/2018-01-wanda-stock-skyrockets-54bn-tencent.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Kulbhushan Jadhav’s native village in Maharashtra erupts with joy after ICJ rulingThere were cheers of joy and sighs of relief as Judge Abdulqawi Ahmed Yusuf, president of the ICJ, read the courts decision in the Kulbhushan Jadhav case and stayed death sentence awarded to him by a military court till Pakistan reviews the trial.advertisement Next Press Trust of India SataraJuly 17, 2019UPDATED: July 17, 2019 20:04 IST Friends of Kulbhushan Jadhav celebrate after ICJ rules in favour of India. (Photo: ANI)Residents of a small village in this western Maharashtra district on Wednesday celebrated as the International Court of Justice (ICJ) stayed the death sentence awarded to local lad Kulbhushan Jadhav by a Pakistan court.There were cheers of joy and sighs of relief as Judge Abdulqawi Ahmed Yusuf, president of the ICJ, read the courts decision in the Kulbhushan Jadhav case and stayed death sentence awarded to him by a military court till Pakistan reviews the trial.The ICJ has ruled in favour of India on merits, affirming Jadhavs right to consular access and notification and directed Pakistan to provide effective review and reconsideration of his conviction and sentences.People in Jadhav’s native Javli village in Satara district condemned Pakistan and demanded the immediate release of the retired Indian Navy officer sentenced to death by a Pakistan army court on alleged “espionage” charges.A villager said that Jadhav has built a house on his farm at Javli and used to visit the village two-three times a year.”The Indian government should get him released at any cost. It is their responsibility. India should pressurise Pakistan to release Kulbhushan Jadhav,” the villager said.Kulbhushan Jadhav is the son of Sudhir Jadhav, a retired Assistant Commissioner of Police in Mumbai. His uncle Subhash Jadhav, also a retired ACP, said, “We are happy that the judgment went in our favour and now await Kulbhushan’s return to India.”At Parel in south Mumbai, where Kulbhushan Jadhav lived for some years, friends and relatives watched the ICJ proceedings live on a TV, with a prayer on their lips.A friend of Kulbhushan said they arranged for a TV set where they would sit together and watch the ICJ ruling. After the ruling, they released balloons and pigeons in the sky as a gesture of peace.Kulbhushan Jadhav’s friends watched the telecast wearing ‘India with Kulbhushan’ T-shirts and also offered special prayers ahead of the ICJ verdict.Also Read | ICJ stays death sentence of Kulbhushan Jadhav: Rajnath Singh, Sushma Swaraj, Chidambaram hail verdictAlso Read | 15-1: Only Pakistan votes against India in Kulbhushan Jadhav verdictAlso Watch | ICJ stays Kulbhushan Jadhav’s execution, asks Pakistan to provide consular accessFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan
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