Share Tuesday, June 20, 2017 MONTREAL — In its 30th anniversary year, Air Transat shows no signs of slowing down with an enhanced flight program to France, its most important destination in Europe.With some 360,000 seats offered annually and an increase in capacity on all its routes to France thanks to its wide-body Airbus A330 aircraft, it’s not surprising that the airline has become known as the preferred airline to the destination for nearly three decades.This year, Air Transat offers direct flights from Montreal to seven of the 10 major cities in France, including Paris, Lyon, Nantes, Toulouse, Nice, Marseille and Bordeaux. Plus, it has been offering flights to Basel-Mulhouse, located at the border between France and Switzerland, since 2008.This summer, travellers from Montreal will have access to: daily direct flights to Paris; five direct flights a week to Marseille; four direct flights a week to Lyon; three direct flights a week to Toulouse; two direct flights a week to Bordeaux, Nantes and Nice; and one direct flight a week to Basel-Mulhouse.More news: Visit Orlando unveils new travel trade tools & agent perksFrom Quebec City, with a connection in Montreal, travellers can take advantage of five flights a week to Paris, four flights a week to Lyon, three flights a week to Marseille, two flights a week to Nantes and Toulouse, and one flight a week to Bordeaux.From Toronto, passengers will have the luxury of choosing between daily flights to Paris, five of which are direct. And, with a connection in Montreal, they can also fly to Marseille (five times a week); Lyon (four times a week); Nantes, Nice and Toulouse (twice a week); and Bordeaux (once a week).Resident of Vancouver will have six chances a week to visit Paris, thanks to three direct flights and three flights with a connection in Toronto. And for the first time this year, they can fly to Bordeaux, Lyon, Marseille and Nice once a week, via Toronto. Travellers from Calgary will have access to four flights a week to Paris thanks to connecting flights.Air Transat also offers a multi-destination flight option, making it possible to land in one city and return from another, at no extra cost. A cultural holiday to France can therefore begin with a stay in Provence by landing in Marseille, and end with a getaway to Paris. Tags: Air Transat, France, New Routes, Transat Posted by Air Transat celebrates more flights to France in its anniversary year Travelweek Group << Previous PostNext Post >>
Travelweek Group Southeast Asia on sale with Scenic, free airfare included Tags: Sales, Scenic Luxury Cruises & Tours, Southeast Asia Posted by Share << Previous PostNext Post >> Thursday, October 25, 2018 VANCOUVER — Scenic Luxury Cruises & Tours in Canada is offering Southeast Asia savings that include a new sailing and free airfare on bookings.Early bookers will receive the lowest prices, says the company, along with first choice on sailing dates and itineraries. Additionally, they can take advantage of US$495 premium economy airfare or free economy flights on Mekong River departures of 13 days and longer, and free economy flights on Irrawaddy River cruises.Booking Scenic’s 11-day sailings on either river means $700 per couple off the fare.These special offers are valid for bookings made by Dec. 31, 2018.New for 2019/2020 is the 18-day ‘Highlights of Vietnam, Cambodia & Luxury Mekong’, which takes the in-depth Vietnam-Cambodia sailing and adds a five-night luxury exploration of the Vietnamese capital of Hanoi and its World Heritage-listed Halong Bay.To support sustainable travel, Scenic guests cruising the Irrawaddy and the Mekong are also given the option to purchase a reusable water bottle to use throughout their journey, reducing the amount of disposable single-use water bottles being used. Filling stations are available throughout the ship and there are also water filling stations at all the shore stops. All funds from the purchase of these reusable bottles are put back into local community projects.More news: Rome enforces ban on sitting on Spanish StepsSince the inception of this program, Scenic has funded 100% of the cost of two projects in South East Asia: the provision of clean running water to the Chiro Community in Kampong Cham, Cambodia, and the construction of new sanitation blocks in Yandabo Village in Myanmar.
Share LAS VEGAS — Radisson has signed the award-winning Treasure Island – TI Hotel & Casino in Las Vegas to its portfolio of hotels, marking the company’s first property on the famous Las Vegas Strip.Featuring nearly 3,000 rooms, the resort will officially join the Radisson system later this year as Treasure Island – TI Hotel & Casino, a Radisson Hotel. Guests will be able to book a stay by late 2019, and Radisson Rewards members will be able to earn and redeem points in 2020.The hotel is located within walking distance of the Sands Expo and is connected by pedestrian bridges leading to Fashion Show shopping mall and Grand Canal Shoppes. It’s home to several upscale and casual dining choices, a spa and world-class entertainment, including Mystère by Cirque du Soleil.As part of the agreement, TI will retain its current branding and exterior signage.“TI is a true resort destination in a one-of-a-kind city, and one we’ve been keen to offer to our loyal guests for quite some time,” said Ken Greene, president, Americas, Radisson Hotel Group. “Treasure Island is home to one of the best locations and values in Las Vegas, and we’re honoured to welcome such a well-known resort and casino to our growing portfolio.” Friday, July 26, 2019 Las Vegas’ Treasure Island to rebrand under Radisson flag Posted by Tags: Las Vegas, Radisson Hotel Group, TH Hotel & Casino, Treasure Island << Previous PostNext Post >> Travelweek Group
Source = The landmark Rendezvous Hotel The landmark Rendezvous Hotel Melbourne was awarded Outstanding Marketed Hotel of the Year at the Australian Hotels Association (Victoria) Accommodation Awards on Friday 20 May, 2011. Held at the Grand Hyatt Melbourne, the event celebrates the leaders of excellence within Victoria’s tourism industry for the 2010-2011 period.It was a big night for Rendezvous Hotel Melbourne, which not only took home the award for Outstanding Marketed Hotel of the Year, but was also a finalist for the Superior Accommodation Hotel of the Year. The Hotel’s employees were also recognised, with finalist nominations for Niall Blundell as the Front Office Service Employee of the Year and David West, who was nominated as Administration Employee of the Year. “We are delighted to take home the Outstanding Marketed Hotel of the Year award, and are so proud of all of the staff, especially those finalists who work so diligently to ensure each guest’s stay is enjoyable in every aspect of the hotel,” said Alexander Billing, of Rendezvous Hotel Melbourne.Rendezvous Hotel Melbourne, which is managed by Rendezvous Hospitality Group, is one of the few grand hotels remaining in Australia. Seeped in travel history since it was built in 1913, the hotel was originally home to the Commercial Travellers Club. Since then, the 4.5 star heritage listed Rendezvous Hotel Melbourne has been meticulously restored to retain the feel and style of the classical 1900’s era, whilst at the same time providing guests with leading 21st century technology and facilities.
Categories: News 05Mar Rep. LaFontaine takes fourth plunge for Special Olympics LANSING, Mich. — State Rep. Andrea LaFontaine once again braced herself for the annual Legislative Polar Plunge on the Capitol lawn. The Columbus Township representative today made her fourth jump for Special Olympics Michigan on the sunny, 13-degree Michigan afternoon.
Categories: Iden News,News State Rep. Brandt Iden of Oshtemo Township will chair the newly created House Ways and Means Committee for the 2019-20 legislative term.Iden will begin his third term representing the 61st House District, which includes part of Kalamazoo County, when the new Legislature convenes in January.The Ways and Means Committee, announced by Speaker-elect Lee Chatfield, will be one of four committees that will advance bills to the House floor. Topics could include tax policy, regulatory reform and commerce, among many others.“I am honored to be appointed to this position and to serve Michigan in this way,” Iden said. “We want to ensure that policies have been fully discussed and debated, and that various perspectives are accounted for.“The people of Michigan deserve a state House that will deliver on top priorities, and will move Michigan forward into the new decade.”The House Ways and Means Committee will review legislation after it has been approved by its original committee, encouraging further deliberation before it is considered by all 110 House members.Iden chaired the House Regulatory Reform Committee during the 2017-18 legislative session. He has served on House committees for Commerce and Trade, Oversight, Communications and Technology, Tax, and Workforce and Talent Development.##### 27Dec Rep. Iden will lead influential new Michigan House committee in 2019-20 legislative session
Legal Marijuana Illinois Is Now the 11th State to Legalize Adult-Use Marijuana — $2B Market Projected –shares Green Entrepreneur Podcast Listen Now Image credit: Aurimas Adomavicius | Getty Images June 26, 2019 Jeffrey L. Smith Illinois Gov. J.B. Pritzker on Tuesday signed a recreational marijuana legalization bill into law, paving the way for the creation of a potential $2 billion market with strong business opportunities.With the signature, Illinois becomes the first state in the country to legalize retail sales through its Legislature and the 11th overall to approve adult use. Pritzker’s signature was considered a fait accompli, since he had pushed legalization and announced his intention to sign the bill as soon as the legislature approved it in late May.“We’re also creating a $30 million low-interest loan program to create opportunity for entrepreneurs in the communities that deserve it the most (from the war on drugs),” Pritzker tweeted Tuesday. Experts believe Illinois’ social equity program, if successful, could become a blueprint for other MJ programs across the country.Marijuana Business Daily projects that the Illinois recreational program, which will launch Jan. 1, 2020, could generate up to $2.5 billion a year depending in part on how many tourists buy MJ products. Illinois is the second state in the Midwest to legalize recreational marijuana. Michigan voters passed a referendum last November that legalized recreational marijuana.The following are key business aspects to the Illinois measure:Existing medical marijuana license holders can begin adult-use sales on Jan. 1, 2020. There currently are 55 licensed dispensaries in the state.Illinois will award permits for up to 75 stores by May 1, 2020 as well as 40 processors and 40 craft growers by July 1, 2020.The measure calls for the state to issue licenses for an additional 110 stores, 60 craft growers and 60 processors in December 2021.Municipalities can prohibit recreational cannabis, although Chicago is expected to be open.Applicants that fall under social equity provisions receive additional points and potential financial resources and support such as low-interest loans, grants, training assistance and mentoring. Next Article This story originally appeared on Marijuana Business Daily Add to Queue Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. 2 min read The legalization measure contains social equity provisions activists believe could be a national model.
2019 Entrepreneur 360 List Contributor Thomas Smale Conferences Add to Queue Next Article Opinions expressed by Entrepreneur contributors are their own. Founder of FE International January 27, 2016 11 Ecommerce Conferences You Should Consider for 2016 Your business can demand major time — especially when you’re first getting set up or you’re in the midst of growing and scaling. But if you burn the candle on both ends, or sacrifice your health and relationships, your efforts are all for naught. Sometimes, it’s necessary to step away from your business to gain perspective.Related: 7 Conferences for Entrepreneurs Under 30Conferences can be a great way to take a break. Traveling to them, participating in their sessions and workshops and networking with other business owners can help you get out of a rut if you’re in one, think more strategically about your business and be in touch with people who can help you.Not that you need to go to every conference that’s out there. What’s important is to take time to recharge, and return to your business ready to tackle new challenges. As a business owner, I’ve also found speaking to be an effective way to grow my business. So, with those things in mind, here is a list, compiled by my team, of 11 of our favorite ecommerce conferences.1. The 10x E-Commerce EventWith over 25 speakers and 18 sessions, the 2016 10x E-Commerce Event this February will focus entirely on tactics you can use to drive more qualified traffic to your site, then convert these people into buying customers. You will learn about the ins and outs of conversion optimization, customer retention, A/B testing, marketing automation and much more.This year’s keynote speakers are Ashlee Vance, Paco Underhill and Timothy Seward. The summit will be held at the Renaissance Orlando at SeaWorld, February 10-12.2. eTail WesteTail West will be held in Palm Springs, California, February 22-25. You’ll have the opportunity to learn about a variety of topics like content marketing, mobile engagement, data and various pain points and areas that affect your business. This year’s keynote speakers include Ron Boire, Kelly McGann, Eric Anderson, Eoin Comerford, Jen Cotter and David Katz.Other eTail events will be held throughout the year at various locations:eTail Germany will be held in Berlin March 8-10.eTail Canada will be in Toronto, Ontario, May 16-19.eTail Europe happens in London, England, June 21-23.eTail East will be in Boston, August 15-18.3. eCommerceFuel LiveeCommerceFuel Live is made up of an exclusive group of six-and-seven-figure independent store owners. This year’s keynote speakers include Miracle Wanzo, Paul Lepa and David Heacock. The event will be held at The Gaylord Opryland in Nashville, Tenn., and will feature world-class musical entertainment. This three-day conference will happen October 7-10.4. MivaconAre you looking to learn about industry best practices, SEO, conversion optimization, content marketing, international ecommerce, trends in ecommerce and other related topics? The beginner-friendly Mivacon will be held in San Diego, March 9-11. The conference schedule has yet to be announced in full, but Rick Wilson will be one of the keynote speakers. 5. Sellers’ Conference For Online EntrepreneursThe Sellers’ Conference for Online Entrepreneurs — or SCOE — will be held in Philadelphia, March 23-25. The speaker roster includes Emily Murray, Rob Wray, Ashvin Kumar, Chris McCabe and others. At SCOE, you will learn about tools and trends in improving your online selling, driving more sales, optimizing your product and service offerings, expanding globally and more. The main focus is on sellers who use Amazon, eBay, Sears, Etsy and the like.Related: Conferences Are Good for Networking but Great for Marketing6. Imagine CommerceImagine Commerce is being held in Las Vegas, April 11-13. A premier Magento commerce conference, Imagine brings together more than 2,500 merchants, developers, partners and experts from more than 45 countries worldwide. Past years’ speakers have included keynotes from Malcolm Gladwell and Steve Wynn and sessions featuring brands and retailers like Toys R Us, Rebecca Minkoff, 3M, Kendra Scott, Zoetis and others.7. Internet Retailer Conference + ExhibitionThe Internet Retailer Conference + Exhibition — or IRCE — offers access to some of the leading industry experts and a one-of-a-kind exhibit hall displaying 600 of the latest solution providers. The 2016 speaker roster is comprised of Raj Aggarwal, Kelli Agnich, Gene Alvarez, Adam Audette, Rick Backus, Amy Ballantyne Rapawy and others.8. Sellers SummitSellers Summit offers an intense “workshop” experience focusing on up-to-date actionable insights — instead of feel-good stories — that entrepreneurs can use to grow their revenues. Speakers include event host Steve Chou, Scott Voelker, Greg Mercer, Toni Anderson, Andrew Youderian, Eric Siu, Spencer Haws, Andreea Ayers, Autumn Wyda, and others. The Sellers Summit takes place in Miami, May 19-21.9. Freedom Fast Lane LiveDetails are as of yet forthcoming for the 2016 Freedom Fast Lane Live conference, but it’s sure to be an incredible experience. Speaker Ryan Moran, for instance, is a true ecommerce expert. At F2L2, you will have the opportunity to meet, connect with and learn from industry leaders to stretch your mindset and be challenged to think beyond what you believe is possible in your business. My team at FE International loved the 2015 event. 10. Retail GlobalRetail Global occurs September 20-22 in Las Vegas. Its primary area of focus will be international commerce. Attendees will have the opportunity to learn from speakers from across the world and build a network of trusted contacts. This year’s speakers have yet to be announced.11. SHOPTALKFocusing on tech-based disruption in ecommerce, SHOPTALK will be held in Las Vegas May 15-18. Its wide range of speakers will include Casey Carl, Daphne Carmeli, Tracy Dinunzio, Ron Johnson, Tim Kendall, Katrina Lake, Raghav Lal, Brian Lee, Marc Lore, Julie Wainright, Janie Yu and others. At SHOPTALK, you can expect to learn the latest trends in engaging consumers.Final thoughtsAs a business owner, you’ll find that the most important investment you can make is in yourself and the future of your business. Conferences give you the chance to learn, grow and connect with others who are successful in their respective fields.Certainly, there are lots of great events out there; and it can be hard to know which to choose. But, ultimately, you will benefit from the experience, no matter what. It isn’t all about what you learn, but rather the decisions you make coming out of a conference, and the new connections you make.Related: 8 Tips to Be an Awesome Networker at Conferences 6 min read –shares The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »
Zilliant’s Annual MindShare 2019 Showcases End-to-End Pricing and Sales Growth Capabilities “It’s an honor to host such a wide array of innovators – longtime customers, companies evaluating Zilliant technology, strategic partners, industry experts – in our hometown,” said Zilliant CEO Greg Peters. “The steep challenges faced by B2B organizations every day are being met head on by our customers, who have harnessed the power of their data and are using Zilliant’s intelligent technology to their advantage.”MindShare focused on distributors, manufacturers and service providers dealing with a rapidly changing business landscape across various industries, with topics such as:B2B eCommerce disruptionAdopting a Pricing Center of ExcellenceDigitization and optimizationPricing modes and methodsDistributor / manufacturer partnershipsOmnichannel pricingMarketing Technology News: Information Builders’ WebFOCUS Named a FrontRunner in Business Intelligence in Fourth Consecutive Report“When disruptors, like Amazon, are duplicating parts of your value proposition, you need to duplicate parts of theirs,” said Ian Heller, President & COO of Modern Distribution Management in his message to attendees. “Traditional B2B companies must scale with technology and become more comfortable doing business online, while offering services that are hard for disruptors to digitize.”A common theme was Zilliant’s comprehensive ability to solve pricing and sales problems big and small, from price list management to advanced, actionable AI-driven pricing and sales guidance.“We wanted to create a data-driven culture as part of our digital transformation journey,” said Mike Eppes, Managing VP of Parts at Rush Enterprises. “Zilliant has become our data science backbone for our parts operations, serving as the nexus for many of our IT systems, from CRM to eCommerce. As a result of using Zilliant’s solutions, we are achieving higher revenue and profits and are better able to anticipate our customers’ needs.”Marketing Technology News: AI-Driven Weather Data: New to Some, But It Has Been Driving CustomWeather’s Success for YearsMindShare featured interactive deep dive sessions led by veteran Zilliant customers. A&O Johansen, a major distributor of technical installation materials and tools in northern Europe, spoke about the real business results they achieved with Zilliant.“We have a very complex environment as both a B2B and B2C provider. The ripple effect of eCommerce down the buyer chain caused inconsistent pricing across channels,” said A&O Johansen CRM Consultant Nadia V. Nielsen. “Zilliant’s Price IQTM solution allowed us to align our prices and roll them out with an optimized, omnichannel B2B2C approach.”IDC’s Research Director for Digital Business Models and Monetization, Mark Thomason, delivered the keynote on business model issues, trends and the challenge of managing pricing in an increasingly global and digitized world.“Using automated pricing technology, such as from Zilliant, is critical to addressing these challenges at scale. Zilliant was named a Leader in the 2018 IDC MarketScape for B2B Price Optimization Applications, and Zilliant customers rated Zilliant very highly in value delivered,” said Thomason.His 2018 report awarded Zilliant with the following plaudits:Shortest time-to-valueHighest return on investmentBest customer satisfactionIf you are interested in the key learnings from the conference content, here are our five takeaways from MindShare 2019.Marketing Technology News: Does Gen Z Marketing Hold Key to Brand Loyalty? Customers from Around the Globe Attend Zilliant’s Annual User Conference AIB2B price optimizationMarketing TechnologyMindShare 2019NewsSaaS-based Price ManagementSales Growth solutionsZilliant Previous ArticleMarTech Interview with Tessa Court, CEO, IntelligenceBankNext ArticleBarracuda launches Advanced Bot Protection Zilliant Showcases End-to-End Pricing and Sales Growth Capabilities at MindShare 2019 PRNewswireMay 28, 2019, 1:37 pmMay 28, 2019 Zilliant, the industry leader in AI-driven pricing and sales growth solutions, hosted its annual MindShare user conference last week in Austin. The company welcomed customers from around the world to share their experiences with Zilliant’s end-to-end suite of SaaS-based Price Management & Optimization and Sales Growth solutions.Attendees participated in keynotes, breakout sessions and hands-on product workshops over three days.
Source:https://www.hptn.org/news-and-events/press-releases/hptn-075-study-demonstrates-high-rate-of-hiv-infection-among-african Reviewed by James Ives, M.Psych. (Editor)Oct 24 2018Researchers from the HIV Prevention Trials Network (HPTN) today presented results from the HPTN 075 Study at the HIV Research for Prevention (HIVR4P) conference in Madrid, Spain. The study evaluated the feasibility of HIV prevention research among men who have sex with men (MSM) and transgender women (TGW) in three countries in sub-Saharan Africa. Findings from the study showed participants were at an alarming risk for getting HIV. The incidence among study participants was substantially higher than the estimated incidence among heterosexual men and women in the general population in the same countries.”Several studies have shown the burden of HIV is quite high among MSM and TGW, but little is known about the rate of new infections, or HIV incidence, among these groups in sub-Saharan Africa,” said Theo Sandfort, PhD, HPTN 075 protocol chair and research scientist, HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University in New York. “The exceptionally high HIV incidence we found indicates an urgent need for increased access to HIV prevention approaches that consider all the factors that put this vulnerable population at such high risk.”Related StoriesHIV therapy leaves unrepaired holes in the immune system’s wall of defenseHIV DNA persists in spinal fluid despite treatment, linked to cognitive impairmentHIV persists in spinal fluid even after long-term treatment and is linked to cognitive deficitsA total of 401 MSM and TGW, regardless of HIV infection status, were enrolled at four sites in Kenya, Malawi and South Africa. Each participant was followed for 12 months, during which five study visits were conducted. These visits included interviewing participants about behaviors that may put them at risk for HIV infection, medical examinations and collection of blood samples. Of the 401 enrolled, 329 were HIV-negative at the time of enrollment. By the end of the study, 21 of them had become infected with HIV. This translates to an overall incidence rate of 6.96 per 100 person-years. Incidence rates differed substantially by study site: Malawi: 1.3; Kenya: 3.75; Soweto, South Africa: 8.97; and Cape Town, South Africa: 14.44.”HPTN 075 provides compelling findings that indicate an urgent need for further HIV prevention studies for men who have sex with men and transgender women in sub-Saharan Africa,” said Wafaa El-Sadr MD, MPH, MPA, HPTN co-principal investigator and professor of epidemiology and medicine at Columbia University in New York. “These studies must examine the realities in which these groups exist and develop integrated intervention strategies that are effective and feasible.””MSM and TGW in sub-Saharan Africa face distinct structural barriers to accessing HIV prevention and treatment,” said Myron Cohen, MD, HPTN co-principal investigator and director of the University of North Carolina at Chapel Hill Institute for Global Health and Infectious Diseases in Chapel Hill, NC. “The HPTN is poised to tackle these barriers as we prioritize this population in our prevention agenda.”
Source:http://www.bmc.org/ Reviewed by James Ives, M.Psych. (Editor)Mar 11 2019Compared to experimental studies that require complex infrastructures such as laboratories or clinical trials at multiple centers, studies using a longitudinal cohort (an observational research method in which data is gathered for the same participants repeatedly over a period of time) could be a good alternative for investigators as they begin their early research careers.”The Framingham Heart Study (FHS) is an excellent example of a database to initiate investigations and generate questions that could be followed later by experimental studies,” explains Hugo J. Aparicio, MD, MPH, assistant professor of neurology at Boston University School of Medicine, in a perspective article in the journal Stroke.Related StoriesOlympus launches next-generation X Line objectives for clinical, research applicationsTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTBridging the Gaps to Advance Research in the Cannabis IndustryFunded by the National Heart, Lung and Blood Institute of the National Institutes of Health, FHS began in 1948, as a database of thousands of participants from Framingham, Mass., who volunteered and shared their medical and personal data to advance clinical knowledge. Over the decades, FHS has helped answer key questions related to cardiovascular and neurological diseases. More than 15,000 participants have been included in FHS studies resulting in nearly 3,700 published articles using the data.According to Aparicio, data from longitudinal cohort studies often contain more detail than administrative datasets, which can result in research with higher quality data that can lead to higher impact publications. In addition, ongoing studies often have well-established research teams and senior investigators with extensive experience. “Access to high-quality data, mentorship and training in the research process are critical for launching a career in clinical research.”However, he cautions that using longitudinal cohort studies does pose some challenges and limitations, including: the way that data is collected makes interpretation of results critical and requires careful insight; loss to follow up when patients drop out of the studies and the difficulty of analyzing rare conditions caused by limited number of participants compared to the total general population.Regardless, Aparicio hopes his perspective article stimulates early career investigators to take advantage of these resources. “Beyond opportunities to publish, joining a research team at a cohort study can open doors for mentorship, expand research skills and help focus and refine your research path.”
Source:https://www.mountsinai.org/about/newsroom/2019/mount-sinai-and-ibm-researchers-uncover-key-to-greater-efficacy-in-cancer-treatment Reviewed by James Ives, M.Psych. (Editor)Mar 22 2019Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy. In a Nature Communications paper published today, researchers reveal for the first time that the number of mitochondria in a cell is, in great part, associated with how the cancer responds to drug therapy.Cancer is the second-leading cause of mortality worldwide, with approximately one in six deaths across the globe attributed to the disease. While treatments for cancer continue to improve as technology advances, researchers and clinicians have been unsuccessful in explaining the diversity of responses in cancer cells to treatments of oncological disease. In many cases, cancer cells with matching genetic makeup will respond differently to the same treatment. Mount Sinai and IBM researchers combined computational and biological methods to uncover a clue to this behavior.Cells die when met with bacteria, malnourishment, or viruses. But also, to promote normal function, our bodies eliminate billions of cells each day–a process known as “programmed cell death” or apoptosis. Mitochondria, often referred to as the powerhouse of the cell because of their ability to produce cellular energy, can also act as a catalyst in the activation of programmed cell death, and certain anti-cancer drugs work by activating this process. This function encouraged researchers to explore the hypothesis that cancer cells with identical genetic makeup, but different quantities of mitochondria, may have varying susceptibility to death if exposed to the same drugs that promote apoptosis.Related StoriesLiving with advanced breast cancerBacteria in the birth canal linked to lower risk of ovarian cancerHow cell-free DNA can be targeted to prevent spread of tumorsIn exposing various types of cells to six concentrations of a pro-apoptotic drug and measuring the abundance of mitochondria within the surviving cells, Mount Sinai and IBM researchers discovered that surviving cells had a greater amount of mitochondria than untreated cells. This strongly suggests that cells with fewer mitochondria are more likely to respond to certain drug treatments.To analyze this data, researchers used a mathematical framework called DEPICTIVE (an acronym for DEtermining Parameter Influence on Cell-to-cell variability Through the Inference of Variance Explained) to quantify variability in the survival or death of cells due to mitochondrial abundance. Overall, the framework determined that the variability of mitochondria explained up to 30 percent of the varying responses to the pro-apoptotic drug.”Enhancing our understanding of the relationship between mitochondria variability and drug response may lead to more effective targeted cancer treatments, allowing us to find new ways to tackle the problem of drug resistance,” said Pablo Meyer, PhD, Adjunct Assistant Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Team Leader of Translational Systems Biology at IBM Research, and co-corresponding author of the publication. “The outcomes of this study were truly multidisciplinary, and only made possible by the strong scientific collaboration established between Mount Sinai and IBM.”
Indeed, Google, Facebook, Instagram, Snap, Spotify, and Amazon, have barely noticed the competitive impact of their Chinese equivalents. While China has found great success in global hardware markets, they have had much less success with software. That is, until now. You may not have heard of it, but TikTok became one of 2018’s most downloaded mobile apps for Apple and Android devices in the US and Europe, unseating the likes of YouTube, Instagram, and Snapchat. TikTok has already been downloaded more than 80m times in the US, logging 4m downloads from the App Store in October alone. It is also one of the most popular apps on Google Play. What is TikTok?TikTok is a video sharing platform with a twist. Videos can be no longer than 15 seconds and they are based on various themes: music, cooking, travel, dance, fashion, and so on. Users create these short videos, use simple tools to add music and special effects, and share them on the site. The most popular clips are high on entertainment value, with a premium on instant gratification. Similar to Vine, which shut down in 2016, TikTok can be thought of as a video version of Instagram or Snapchat. TikTok comes from China, but, interestingly, it is not owned by one of the Chinese tech giants. Despite massive investments in video platforms by the likes of Alibaba, Tencent, and Baidu, none of them dominates this area. TikTok – known locally as Douyin – was launched in 2016 by ByteDance, a Beijing-based tech company traditionally focused on news. Its news app, called Toutiao, uses advanced AI algorithms that learn user preferences, then provides customised news feeds. Bytedance uses the same algorithms to provide relevant video feeds to TikTok users. By the start of 2017, Douyin had become China’s most popular mobile video app. In November of the same year, ByteDance spent US$1 billion to acquire a competing video sharing site called Musical.ly. While Musical.ly was also founded in China, most of its users were based in the US. The combined global reach of TikTok and Musical.ly made for a powerful combination. Anticipation has long been building about the impending takeover of the tech world by Chinese digital giants like Alibaba, Tencent, Baidu, and JD. Efforts so far, however, have been largely disappointing. The most popular messaging app in the West is WhatsApp, not WeChat; people use PayPal, not Alipay, for digital payments; Google dominates the search market, not Baidu. Credit: Ricky Kresslein / Shutterstock.com As TikTok videos take hold with teens, parents scramble to keep up This article is republished from The Conversation under a Creative Commons license. Read the original article. Provided by The Conversation Explore further While many social media applications focus on global consistency and reach, TikTok focused on targeting specific local audiences. For example, in Japan, TikTok collaborated with a large artist management company to drive traffic from YouTube and Instagram using watermarked TikTok videos created by local celebrities. It also ran a series of dancing and music campaigns focused on overcoming shyness, an issue for many young people in Japan. Challenges are one of the key elements of TikTok. These are video skits that get acted out on masse, with people creating various responses to a popular meme. A recent one involved gummy bears singing an Adele song, which got 1.7m likes on TikTok, went viral on Twitter and spawned numerous spinoffs. Competition loomsBy the end of 2018, TikTok had more than a half-billion active users (more than Twitter) – around 40% of them outside China. It is no surprise that the Chinese giants are closely studying TikTok’s successful approach of simple design, active promotion, attention to different locales, and focused acquisition, with an eye to understanding and emulating the magic formula for succeeding in global markets. Tencent is already making a bet on the short-video streaming industry by investing in Kuaishou, TikTok’s main local competitor, and reportedly giving out subsidies worth nearly US$500m to promote its own platform Weishi. The giants of the West are also taking note, with Facebook quietly launching a TikTok competitor app called Lasso in November 2018. Meanwhile, Bytedance recently completed a new round of funding led by major tech investor SoftBank. This valued the company behind TikTok at US$75 billion, making it the world’s most valuable startup, higher even than Uber. Bytedance cannot rest on its laurels, however, if it wants TikTok to build on its position as the first globally successful “made in China” app. TikTok will need to massively expand from its base, while staving off attacks from well funded and ambitious Chinese and global competitors. Building a successful app is one thing. But, as Snapchat’s fall from grace shows, sustaining that success is an entirely more challenging endeavour. Citation: TikTok: the world’s most valuable startup that you’ve never heard of (2019, January 8) retrieved 17 July 2019 from https://phys.org/news/2019-01-tiktok-world-valuable-startup-youve.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
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NDA’s Rafale deal 2.86% cheaper than UPA’s: CAG RELATED CAG report on Rafale: Lies of ‘Mahajhootbandhan’ stand exposed, says Jaitley defence contract Mirage 2000 used due to high success rate against long-range targets defence COMMENTS How the IAF compares with the PAF Undeterred by losing Rafale, buoyant HAL wants to develop own products An investigation into the theft is on, Attorney general K K Venugopal said ‘Modi sacrificed national interest’ COMMENT March 06, 2019 Published on SHARE SHARE EMAIL Rafale performing, during the AERO INDIA 2019 at IAF station Yelahanka – THE HINDU Supreme Court of India Rafale No scandal in Rafale deal: Dassault Aviation CEO SHARE defence equipment The Centre, which accused former Union Ministers Yashwant Sinha and Arun Shourie and lawyer Prashant Bhushan of relying on stolen documents to seek a review of the judgment dismissing petitions on the Rafale deal, faced searching queries from the Supreme Court. “Are these documents untouchable” for consideration by the courts, it was asked.“We can understand you saying petitioners came with unclean hands. That they got the documents through doubtful sources. But it is another thing to say the court cannot consider these documents at all. That they are untouchable,” said a Bench headed by Chief Justice Ranjan Gogoi.The remarks came when Attorney General KK Venugopal insisted that the review petitions and a perjury application filed in the matter have to be dismissed as the petitioners were averse to disclosing the sources of the documents which were stolen from the Defence Ministry. The high voltage hearing witnessed the Bench asking the Centre: “When there is allegation of corruption, can the government take shelter under national security? If an act of corruption is committed in Rafale deal, will the government take shelter behindthe Official Secrets Act?” It further said it is settled in a catena of judgments that even if stolen documents are cited, and if they are found relevant, the court can look into them.The Bofors exampleDuring the hearing, the Bench also mentioned the Bofors scam and said: “There were allegations of corruption in Bofors. Now, will you say the same thing — that a criminal court shouldn’t look into any such document in that case? Here we have an open system.”The Attorney General replied: “Yes, we have an extremely open system here. This is the only country where a court is examining a defence deal as if it is an administrative issue. No other court in any other country will do it.”The Bench said if the documents were stolen, the government should put its own house in order. “It is one thing to say that we should look at these documents with suspicion. But to say we can’t even look at those documents may not be a correct submission in law,” it observed.The issue of stolen documents was raised by Venugopal when Bhushan submitted an eight-page note to the bench. The Attorney General said the contents of the documents were based on stolen materials and an investigation is under way.Venugopal drew the attention of the Bench to a news item published in The Hindu and contended that such publication amounted to an offence under the OSA.
Amid the leadership crises in the Congress, Rahul Gandhi on Wednesday reportedly told the Congress Parliamentary Party that his decision to quit as party president is final.The Congress Parliamentary Party, headed by Sonia Gandhi, met this morning in Parliament precinct where the issue of Rahul Gandhi taking sole responsibility for the party’s defeat in the Lok Sabha election was reportedly raised.Some MPs, including Shashi Tharoor and Manish Tiwari, have reportedly told him that the blame for the party’s defeat cannot be taken by just one individual. Simultaneously, there was a sit-in outside Rahul Gandhi’s house by Youth Congress members who urged him to reconsider his decision. Joined by senior leaders — Shakti Singh Gohil and JD Seelam — they shouted slogans demanding Rahul’s return.‘Rahul, a strong leader’“Indian Youth Congress firmly believes that only Rahul Gandhi is capable of providing strong leadership and pose resistance. While it is a fact that the Congress party has suffered a setback at the national level, this had happened in the past too and the party has sprung back with renewed energy every time. The victory of communal forces has led to apprehension and concern in the minds of all those who believe in secular and democratic values. In such a situation, Rahul Gandhi should lead the party,” said a statement issued by the Youth Congress.This is not the first time Rahul Gandhi has repeated his resolve to quit. There have been multiple meetings of the Congress top leaders since the party lost heavily to the BJP in the May 23 elections. Following the election results, Rahul offered his resignation during a meeting of the Congress Working Committee on May 25. While the CWC rejected the offer, Rahul has remained firm. It was initially decided that he would continue for a month till the party finds an alternative. But now at the end of the month, the Congress still remains rudderless.Meanwhile, the it is facing relentless attacks and gibes in both Houses of Parliament with the Prime Minister Narendra Modi himself leading the blistering charge. Besides the PM’s attack, other BJP MPs, too, have been openly questioning the Congress on the leadership crises. “Does the Congress have a President? Does anyone know?” asked BJP MP from Hazaribagh Jayant Sinha during the debate on the motion of thanks to the President in the Lok Sabha. SHARE SHARE EMAIL SHARE COMMENT Published on June 26, 2019 COMMENTS